Efficacy of cabbage leaf wraps in the treatment of symptomatic osteoarthritis of the knee a randomized controlled trial

Lauche, R; Gräf, N; Cramer, H; Al-Abtah, J; Dobos, G; Saha, FJ

Efficacy of cabbage leaf wraps in the treatment of symptomatic osteoarthritis of the knee a randomized controlled trial

Lauche, R

Gräf, N Cramer, H Al-Abtah, J Dobos, G Saha, FJ

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Publication Type:: Journal Article
Citation:: Clinical Journal of Pain, 2016, 32 (11), pp. 961 - 971
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Lauche, R https://orcid.org/0000-0002-4171-7935	en_US
dc.contributor.author	Gräf, N	en_US
dc.contributor.author	Cramer, H	en_US
dc.contributor.author	Al-Abtah, J	en_US
dc.contributor.author	Dobos, G	en_US
dc.contributor.author	Saha, FJ	en_US
dc.date.issued	2016-01-01	en_US
dc.identifier.citation	Clinical Journal of Pain, 2016, 32 (11), pp. 961 - 971	en_US
dc.identifier.issn	0749-8047	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41877
dc.description.abstract	Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Objectives: Osteoarthritis (OA) of the knee is one of the most common chronic diseases among older adults. This study aimed to test the effects of cabbage leaf wraps (CLWs) in the treatment of symptomatic OA. Methods: Patients with OA of the knee at stages II to III (Kellgren-Lawrence) were randomly assigned to 4 weeks of treatment with CLWs (daily for at least 2h), topical pain gel (TPG) (10mg diclofenac/g, at least once daily), or usual care (UC). The primary outcome measure was pain intensity (VAS) after 4 weeks. Secondary outcomes included functional disability Western Ontario and McMaster Universities Arthritis Index (WOMAC), quality of life (SF-36), self-efficacy (Arthritis Self-Efficacy Scale-D), physical function (30 s Chair Stand Test), pressure pain sensitivity (PPT), satisfaction, and safety after 4 and 12 weeks. Results: In total, 81 patients were included in this study (42 women, 65.9±10.3 y). After 4 weeks patients in the CLW group reported significantly less pain compared with those in the UC group (difference, -12.1; 95% [confidence interval] CI, -23.1, -1.0; P=0.033) but not when compared with the TPG group (difference, -8.6; 95% CI, -21.5, 4.4; P=0.190). Significant effects were also found in WOMAC, SF-36, 30-second Chair Stand Test, and PPT scores in the CLW group compared with the UC group. Compared with TPG, effects from CLW were found for WOMAC after 4 weeks and for quality of life after 12 weeks. Patients were satisfied with both active interventions, and except for 2 adverse events in both groups the applications were well tolerated. Conclusions: CLWs are more effective for knee OA than UC, but not compared with diclofenac gel. Therefore, they might be recommended for patients with OA of the knee. Further research is warranted.	en_US
dc.relation.ispartof	Clinical Journal of Pain	en_US
dc.relation.isbasedon	10.1097/AJP.0000000000000352	en_US
dc.subject.classification	Anesthesiology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Brassica	en_US
dc.subject.mesh	Plant Leaves	en_US
dc.subject.mesh	Osteoarthritis, Knee	en_US
dc.subject.mesh	Diclofenac	en_US
dc.subject.mesh	Anti-Inflammatory Agents, Non-Steroidal	en_US
dc.subject.mesh	Gels	en_US
dc.subject.mesh	Pain Measurement	en_US
dc.subject.mesh	Disability Evaluation	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Phytotherapy	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Quality of Life	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Patient Satisfaction	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Pain Management	en_US
dc.title	Efficacy of cabbage leaf wraps in the treatment of symptomatic osteoarthritis of the knee a randomized controlled trial	en_US
dc.type	Journal Article
utslib.citation.volume	11	en_US
utslib.citation.volume	32	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1109 Neurosciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	open_access
pubs.issue	11	en_US
pubs.publication-status	Published	en_US
pubs.volume	32	en_US

Abstract:

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Objectives: Osteoarthritis (OA) of the knee is one of the most common chronic diseases among older adults. This study aimed to test the effects of cabbage leaf wraps (CLWs) in the treatment of symptomatic OA. Methods: Patients with OA of the knee at stages II to III (Kellgren-Lawrence) were randomly assigned to 4 weeks of treatment with CLWs (daily for at least 2h), topical pain gel (TPG) (10mg diclofenac/g, at least once daily), or usual care (UC). The primary outcome measure was pain intensity (VAS) after 4 weeks. Secondary outcomes included functional disability Western Ontario and McMaster Universities Arthritis Index (WOMAC), quality of life (SF-36), self-efficacy (Arthritis Self-Efficacy Scale-D), physical function (30 s Chair Stand Test), pressure pain sensitivity (PPT), satisfaction, and safety after 4 and 12 weeks. Results: In total, 81 patients were included in this study (42 women, 65.9±10.3 y). After 4 weeks patients in the CLW group reported significantly less pain compared with those in the UC group (difference, -12.1; 95% [confidence interval] CI, -23.1, -1.0; P=0.033) but not when compared with the TPG group (difference, -8.6; 95% CI, -21.5, 4.4; P=0.190). Significant effects were also found in WOMAC, SF-36, 30-second Chair Stand Test, and PPT scores in the CLW group compared with the UC group. Compared with TPG, effects from CLW were found for WOMAC after 4 weeks and for quality of life after 12 weeks. Patients were satisfied with both active interventions, and except for 2 adverse events in both groups the applications were well tolerated. Conclusions: CLWs are more effective for knee OA than UC, but not compared with diclofenac gel. Therefore, they might be recommended for patients with OA of the knee. Further research is warranted.

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http://hdl.handle.net/10453/41877