Chiral analysis of methadone and its major metabolites (EDDP and EMDP) by liquid chromatography-mass spectrometry

Elsevier Science Bv
Publication Type:
Journal Article
Journal Of Chromatography B-Analytical Technologies In The Biomedical And Life Sciences, 2005, 814 (2), pp. 315 - 323
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Racemic methadone (MET) is administered to heroin users undergoing methadone maintenance therapy (MMT) in Australia. The enantiomers of methadone possess different pharmacological effects, and the enantioselective metabolism of methadone to its two major
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