Factors associated with HBV virological breakthrough
Sheppard-Law, S
Zablotska-Manos, I
Kermeen, M
Holdaway, S
Lee, A
Zekry, A
Dore, GJ
George, J
Maher, L
- Publication Type:
- Journal Article
- Citation:
- Antiviral Therapy, 2017, 22 (1), pp. 53 - 60
- Issue Date:
- 2017-01-01
Open Access
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author |
Sheppard-Law, S |
en_US |
dc.contributor.author | Zablotska-Manos, I | en_US |
dc.contributor.author | Kermeen, M | en_US |
dc.contributor.author | Holdaway, S | en_US |
dc.contributor.author | Lee, A | en_US |
dc.contributor.author | Zekry, A | en_US |
dc.contributor.author | Dore, GJ | en_US |
dc.contributor.author | George, J | en_US |
dc.contributor.author | Maher, L | en_US |
dc.date.available | 2016-08-26 | en_US |
dc.date.issued | 2017-01-01 | en_US |
dc.identifier.citation | Antiviral Therapy, 2017, 22 (1), pp. 53 - 60 | en_US |
dc.identifier.issn | 1359-6535 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/59182 | |
dc.description.abstract | ©2017 International Medical Press. Background: Little is known about non-adherence to HBV therapy. This study aimed to investigate the relationship between self-reported missed days of antiviral therapy and HBV virological breakthrough and factors associated with virological breakthrough. Methods: A cross-sectional survey of 211 HBV patients receiving oral antiviral therapies was undertaken at three tertiary hospitals in Sydney, Australia. Associations between 0 to >6 missed days in the last 30 days and virological breakthrough (defined as >10-fold rise in serum HBV DNA above nadir or after achieving virological response in the last 12 months) were examined. Logistic regression analyses determined the number of missed days most strongly associated with virological breakthrough and the associated factors. We report odds ratios (ORs) and relative risks (RRs). Results: Of the 204, 32 participants (15.6%) had quantifiable HBV DNA levels (>20 IU/ml); 15 (46.8%) of them experienced virological breakthrough. Participants reported never missing medication (n=130, 63.7%) or missing 1 day (n=23, 11.3%), >1 day (n=23, 11.3%), 2-6 days (n=15, 7.3%) and >6 days (n=13, 6.4%). The most discriminating definition of non-adherence was missing >1 day of medication (RR=8.3; OR=10.2, 95% CI 3.1, 33.8, receiver operating characteristic curve 0.76). Factors independently associated with virological breakthrough included non-adherence (OR=9.0, 95% CI 2.5, 31.9) diagnosed with HBV ≤14 years (OR=5.3, 95% CI 1.0, 26.2) and age ≤47 years (OR=5.4, 95% CI 1.1, 26.9). Conclusions: Results provide an evidence-based definition of non-adherence to inform clinical practice and provide a basis for key patient education messages. Closer monitoring of groups at risk of viral breakthrough is required. | en_US |
dc.relation.ispartof | Antiviral Therapy | en_US |
dc.relation.isbasedon | 10.3851/IMP3087 | en_US |
dc.subject.classification | Virology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hepatitis B virus | en_US |
dc.subject.mesh | Hepatitis B, Chronic | en_US |
dc.subject.mesh | DNA, Viral | en_US |
dc.subject.mesh | Antiviral Agents | en_US |
dc.subject.mesh | Treatment Failure | en_US |
dc.subject.mesh | Viral Load | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Cross-Sectional Studies | en_US |
dc.subject.mesh | Evidence-Based Medicine | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Australia | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Medication Adherence | en_US |
dc.subject.mesh | Young Adult | en_US |
dc.subject.mesh | Self Report | en_US |
dc.subject.mesh | Sustained Virologic Response | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Antiviral Agents | en_US |
dc.subject.mesh | Australia | en_US |
dc.subject.mesh | Cross-Sectional Studies | en_US |
dc.subject.mesh | DNA, Viral | en_US |
dc.subject.mesh | Evidence-Based Medicine | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hepatitis B virus | en_US |
dc.subject.mesh | Hepatitis B, Chronic | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Medication Adherence | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Self Report | en_US |
dc.subject.mesh | Sustained Virologic Response | en_US |
dc.subject.mesh | Treatment Failure | en_US |
dc.subject.mesh | Viral Load | en_US |
dc.subject.mesh | Young Adult | en_US |
dc.title | Factors associated with HBV virological breakthrough | en_US |
dc.type | Journal Article | |
utslib.description.version | Published | en_US |
utslib.citation.volume | 1 | en_US |
utslib.citation.volume | 22 | en_US |
utslib.for | 1103 Clinical Sciences | en_US |
utslib.for | 0605 Microbiology | en_US |
utslib.for | 1108 Medical Microbiology | en_US |
utslib.for | 0605 Microbiology | en_US |
utslib.for | 1103 Clinical Sciences | en_US |
utslib.for | 1108 Medical Microbiology | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
utslib.copyright.status | open_access | |
utslib.copyright.embargo | 2017-09-30T00:00:00+1000 | |
pubs.issue | 1 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 22 | en_US |
Files in This Item:
Filename | Description | Size | |||
---|---|---|---|---|---|
FACTORS ASSOCIATED WITH HEPATITIS B VIRUS VIROLOGICAL BREAKTHROUGH submitted.pdf | Submitted Version | 710.33 kB | Adobe PDF |
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Abstract:
©2017 International Medical Press. Background: Little is known about non-adherence to HBV therapy. This study aimed to investigate the relationship between self-reported missed days of antiviral therapy and HBV virological breakthrough and factors associated with virological breakthrough. Methods: A cross-sectional survey of 211 HBV patients receiving oral antiviral therapies was undertaken at three tertiary hospitals in Sydney, Australia. Associations between 0 to >6 missed days in the last 30 days and virological breakthrough (defined as >10-fold rise in serum HBV DNA above nadir or after achieving virological response in the last 12 months) were examined. Logistic regression analyses determined the number of missed days most strongly associated with virological breakthrough and the associated factors. We report odds ratios (ORs) and relative risks (RRs). Results: Of the 204, 32 participants (15.6%) had quantifiable HBV DNA levels (>20 IU/ml); 15 (46.8%) of them experienced virological breakthrough. Participants reported never missing medication (n=130, 63.7%) or missing 1 day (n=23, 11.3%), >1 day (n=23, 11.3%), 2-6 days (n=15, 7.3%) and >6 days (n=13, 6.4%). The most discriminating definition of non-adherence was missing >1 day of medication (RR=8.3; OR=10.2, 95% CI 3.1, 33.8, receiver operating characteristic curve 0.76). Factors independently associated with virological breakthrough included non-adherence (OR=9.0, 95% CI 2.5, 31.9) diagnosed with HBV ≤14 years (OR=5.3, 95% CI 1.0, 26.2) and age ≤47 years (OR=5.4, 95% CI 1.1, 26.9). Conclusions: Results provide an evidence-based definition of non-adherence to inform clinical practice and provide a basis for key patient education messages. Closer monitoring of groups at risk of viral breakthrough is required.
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