Classification of the biopolymer sodium pentosan polysulfate by infrared spectroscopy

Foot, M; Mulholland, M; Kirkup, L

Classification of the biopolymer sodium pentosan polysulfate by infrared spectroscopy

Foot, M Mulholland, M Kirkup, L

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Publication Type:: Journal Article
Citation:: Chromatographia, 2003, 58 (5-6), pp. 343 - 348
Issue Date:: 2003-09-01

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Field	Value	Language
dc.contributor.author	Foot, M	en_US
dc.contributor.author	Mulholland, M	en_US
dc.contributor.author	Kirkup, L	en_US
dc.date.issued	2003-09-01	en_US
dc.identifier.citation	Chromatographia, 2003, 58 (5-6), pp. 343 - 348	en_US
dc.identifier.issn	0009-5893	en_US
dc.identifier.uri	http://hdl.handle.net/10453/647
dc.description.abstract	Sodium pentosan polysulfate (NaPPS) is a glycosaminoglycan that is of increasing interest due to its medical properties. It has been investigated for the treatment of osteoarthritis, HIV and Prion based diseases. This work describes an investigation into the application of infrared spectroscopy (IR) for the differentiation between sources of NaPPS. Multivariate techniques such as principle components analysis were applied to detect differences between the IR and near IR (NIR) spectra and to classify the biopolymers based on their manufacturer. This study compared two samples of NaPPS from different manufacturers. Principle components analysis (PCA) together with soft independent modeling of class analogies (SIMCA) was used to successfully classify the different samples. Clear differentiation between all batches was achieved using PCA and class distances using first derivative spectra (500-1800 cm-1).	en_US
dc.relation.ispartof	Chromatographia	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.title	Classification of the biopolymer sodium pentosan polysulfate by infrared spectroscopy	en_US
dc.type	Journal Article
utslib.citation.volume	5-6	en_US
utslib.citation.volume	58	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0399 Other Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Chemistry and Forensic Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	5-6	en_US
pubs.publication-status	Published	en_US
pubs.volume	58	en_US

Abstract:

Sodium pentosan polysulfate (NaPPS) is a glycosaminoglycan that is of increasing interest due to its medical properties. It has been investigated for the treatment of osteoarthritis, HIV and Prion based diseases. This work describes an investigation into the application of infrared spectroscopy (IR) for the differentiation between sources of NaPPS. Multivariate techniques such as principle components analysis were applied to detect differences between the IR and near IR (NIR) spectra and to classify the biopolymers based on their manufacturer. This study compared two samples of NaPPS from different manufacturers. Principle components analysis (PCA) together with soft independent modeling of class analogies (SIMCA) was used to successfully classify the different samples. Clear differentiation between all batches was achieved using PCA and class distances using first derivative spectra (500-1800 cm-1).

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http://hdl.handle.net/10453/647