The CCK(2) agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat.

McLachlan, CS; Farook, JM; Daugé, V; Wong, PT

The CCK(2) agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat.

McLachlan, CS Farook, JM Daugé, V Wong, PT

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Publication Type:: Journal Article
Citation:: Peptides, 2009, 30 (4), pp. 808 - 809
Issue Date:: 2009-04

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Field	Value	Language
dc.contributor.author	McLachlan, CS	en_US
dc.contributor.author	Farook, JM	en_US
dc.contributor.author	Daugé, V	en_US
dc.contributor.author	Wong, PT	en_US
dc.date.available	2008-12-17	en_US
dc.date.issued	2009-04	en_US
dc.identifier.citation	Peptides, 2009, 30 (4), pp. 808 - 809	en_US
dc.identifier.uri	http://hdl.handle.net/10453/8482
dc.description.abstract	BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20min cat exposure were calculated. At higher doses (15 or 30microg/kg) but not lower doses (0.1-1microg/kg) BC264 statistically significantly decreased freezing compared to control (p<0.001).	en_US
dc.language	eng	en_US
dc.relation.ispartof	Peptides	en_US
dc.relation.isbasedon	10.1016/j.peptides.2008.12.013	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Cats	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Cholecystokinin	en_US
dc.subject.mesh	Peptide Fragments	en_US
dc.subject.mesh	Receptor, Cholecystokinin B	en_US
dc.subject.mesh	Predatory Behavior	en_US
dc.subject.mesh	Fear	en_US
dc.subject.mesh	Dose-Response Relationship, Drug	en_US
dc.title	The CCK(2) agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat.	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	30	en_US
utslib.location.activity	United States	en_US
utslib.for	030406 Proteins and Peptides	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	0606 Physiology	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
dc.location.activity	ISI:000265514100025	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	30	en_US

Abstract:

BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20min cat exposure were calculated. At higher doses (15 or 30microg/kg) but not lower doses (0.1-1microg/kg) BC264 statistically significantly decreased freezing compared to control (p<0.001).

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http://hdl.handle.net/10453/8482