The CCK(2) agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat.

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Journal Article
Peptides, 2009, 30 (4), pp. 808 - 809
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BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20min cat exposure were calculated. At higher doses (15 or 30microg/kg) but not lower doses (0.1-1microg/kg) BC264 statistically significantly decreased freezing compared to control (p<0.001).
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