Percutaneous microwave ablation with a long side-firing antenna array can successfully treat a nonsurgical chronic ovine atrial flutter model
- Publication Type:
- Journal Article
- Journal of Cardiovascular Electrophysiology, 2009, 20 (11), pp. 1255 - 1261
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Microwave Ablation of an Ovine Atrial Flutter Model. Introduction: Long side-firing microwave (MW) arrays can deliver energy uniformly over its length without the need for intimate endocardial contact. We hypothesize that a novel 6 Fr 20 mm long percutaneous high-efficiency MW antenna array ablation catheter can rapidly create long, continuous, and transmural linear ablation lesions. Methods and Results: Cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) was created in 11 sheep by a line of radiofrequency ablation lesions in the posterior right atrium (RA) linking the venae cavae. After 4-6 weeks recovery, CTI-dependent AFL was still inducible in all 11 sheep (cycle length 178 ± 13 ms). MW ablation of the CTI at 100 W for 30 seconds was then performed with an endpoint of AFL noninducibility. AFL was not inducible in all 11 sheep after 4.3 ± 3.3 MW applications (129 ± 99 seconds). The last 6 animals needed fewer ablations (2.2 ± 1.5) and 3 of these sheep required only a single ablation. Although conduction times from proximal coronary sinus to lateral RA and vice versa increased postablation (51 ± 14 ms to 118 ± 31 ms [P = 0.0002] and 60 ± 13 ms to 119 ± 28 ms [P = 0.0001], respectively), AFL was still inducible in 2 sheep and further ablation was needed to reach the endpoint. Conclusions: High-efficiency side-firing MW array ablation can rapidly create long linear and electrically intact lesions in an ovine AFL model. AFL noninducibility may be a more reliable indicator than CTI conduction times of an intact line of ablation in this animal model. © 2009 Wiley Periodicals, Inc.
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