Vitamin D, PTH and calcium levels in pregnant women and their neonates

Bowyer, L; Catling-Paull, C; Diamond, T; Homer, C; Davis, G; Craig, ME

Vitamin D, PTH and calcium levels in pregnant women and their neonates

Bowyer, L Catling-Paull, C

Diamond, T Homer, C

Davis, G Craig, ME

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Publication Type:: Journal Article
Citation:: Clinical Endocrinology, 2009, 70 (3), pp. 372 - 377
Issue Date:: 2009-03-01

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Field	Value	Language
dc.contributor.author	Bowyer, L	en_US
dc.contributor.author	Catling-Paull, C https://orcid.org/0000-0001-7352-2879	en_US
dc.contributor.author	Diamond, T	en_US
dc.contributor.author	Homer, C https://orcid.org/0000-0002-7454-3011	en_US
dc.contributor.author	Davis, G	en_US
dc.contributor.author	Craig, ME	en_US
dc.date.issued	2009-03-01	en_US
dc.identifier.citation	Clinical Endocrinology, 2009, 70 (3), pp. 372 - 377	en_US
dc.identifier.issn	0300-0664	en_US
dc.identifier.uri	http://hdl.handle.net/10453/9719
dc.description.abstract	Objectives : To determine the prevalence of vitamin D deficiency in pregnant women and their neonates and to examine factors associated with vitamin D deficiency. Design and patients : Population-based study of pregnant women and their neonates from South-eastern Sydney, Australia. Measurements : Serum 25 hydroxy-vitamin D (25-OHD), PTH, calcium, albumin, phosphate and alkaline phosphatase were measured in women at 23-32 weeks gestation and on cord blood at delivery. Maternal skin phototype was recorded using the Fitzpatrick scale. Results : Vitamin D deficiency (defined as 25-OHD ≤ 25 nmol/l) was found in 144 of 971 (15%) women and 98 of 901 (11%) neonates. Median 25-OHD was 52 nmol/l (range 17-174) in mothers and 60 nmol/l (17-245) in neonates. Maternal 25-OHD levels varied by season, with lowest levels in late winter/early spring (P < 0·001). Factors associated with maternal vitamin D deficiency in multiple logistic regression were (OR, 95% CI): maternal birthplace outside Australia: 2·2 (1·4-3·5, P = 0·001), dark skin phototype: 2·7 (1·6-4·5, P < 0·001), wearing a veil: 21·7 (11·7-40·3, P < 0·001) and younger maternal age: 0·93 (0·89-0·97, P = 0·001). Maternal vitamin D deficiency increased the risk of neonatal vitamin D deficiency (OR 17·2, 95% CI 8·8-34·3) and birth weight was lower among infants of deficient vs. sufficient mothers: mean (SD) 3245 g (545) vs. 3453 g (555), P < 0·001. Conclusions : Vitamin D deficiency is common among pregnant women; immigrant, veiled and dark skinned women are at greatest risk. Maternal vitamin D deficiency increases the risk of neonatal vitamin D deficiency and lower birth weight. © 2009 Blackwell Publishing Ltd.	en_US
dc.relation.ispartof	Clinical Endocrinology	en_US
dc.relation.isbasedon	10.1111/j.1365-2265.2008.03316.x	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Vitamin D Deficiency	en_US
dc.subject.mesh	Phosphates	en_US
dc.subject.mesh	Calcium	en_US
dc.subject.mesh	Parathyroid Hormone	en_US
dc.subject.mesh	Alkaline Phosphatase	en_US
dc.subject.mesh	Vitamin D	en_US
dc.subject.mesh	Incidence	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Longitudinal Studies	en_US
dc.subject.mesh	Sunlight	en_US
dc.subject.mesh	Seasons	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Phenotype	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Infant, Low Birth Weight	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.title	Vitamin D, PTH and calcium levels in pregnant women and their neonates	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	70	en_US
utslib.for	110306 Endocrinology	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
dc.location.activity	ISI:000263301400005	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Midwifery
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Strength - WHO CC
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	70	en_US

Abstract:

Objectives : To determine the prevalence of vitamin D deficiency in pregnant women and their neonates and to examine factors associated with vitamin D deficiency. Design and patients : Population-based study of pregnant women and their neonates from South-eastern Sydney, Australia. Measurements : Serum 25 hydroxy-vitamin D (25-OHD), PTH, calcium, albumin, phosphate and alkaline phosphatase were measured in women at 23-32 weeks gestation and on cord blood at delivery. Maternal skin phototype was recorded using the Fitzpatrick scale. Results : Vitamin D deficiency (defined as 25-OHD ≤ 25 nmol/l) was found in 144 of 971 (15%) women and 98 of 901 (11%) neonates. Median 25-OHD was 52 nmol/l (range 17-174) in mothers and 60 nmol/l (17-245) in neonates. Maternal 25-OHD levels varied by season, with lowest levels in late winter/early spring (P < 0·001). Factors associated with maternal vitamin D deficiency in multiple logistic regression were (OR, 95% CI): maternal birthplace outside Australia: 2·2 (1·4-3·5, P = 0·001), dark skin phototype: 2·7 (1·6-4·5, P < 0·001), wearing a veil: 21·7 (11·7-40·3, P < 0·001) and younger maternal age: 0·93 (0·89-0·97, P = 0·001). Maternal vitamin D deficiency increased the risk of neonatal vitamin D deficiency (OR 17·2, 95% CI 8·8-34·3) and birth weight was lower among infants of deficient vs. sufficient mothers: mean (SD) 3245 g (545) vs. 3453 g (555), P < 0·001. Conclusions : Vitamin D deficiency is common among pregnant women; immigrant, veiled and dark skinned women are at greatest risk. Maternal vitamin D deficiency increases the risk of neonatal vitamin D deficiency and lower birth weight. © 2009 Blackwell Publishing Ltd.

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http://hdl.handle.net/10453/9719