Study on the postmortem redistribution of diazepam and nordiazepam in poisoned rats

Publisher:
Forensic Medicine Association of China
Publication Type:
Journal Article
Citation:
Chinese Journal of Forensic Medicine, 2016, 31 (3), pp. 235 - 237
Issue Date:
2016
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bjective To explore the postmortem redistribution of diazepam and nordiazepam in acute poisoned rats. Methods The 24 rats in experimental group were randomly divided into eight groups,and given intragastric ministration of diazepam with a dose of 90 mg/kg, 2h later, they are executed by hypoxia method and then they are preserved at temperature of 10℃. Cardiac, liver, spleen, lung, kidney, brain and muscle are taken out to detect diazepam and nordiazepam at different times after death(0h, 2h, 4h, 8h, 12 h, 24 h, 48 h, 96h), which were then extracted with a solid phase extraction(SPE) and determined by HPLC-MS-MS. Results The distribution regularities of diazepam and nordiazepam of different visceras in acute poisoned rats would change by the time. Conclusion The diazepam and nordiazepam in acute poisoned rats could have the postmortem redistribution.
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