Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers

Wong, EHH; Khin, MM; Ravikumar, V; Si, Z; Rice, SA; Chan-Park, MB

Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers

Wong, EHH Khin, MM Ravikumar, V Si, Z Rice, SA

Chan-Park, MB

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Publication Type:: Journal Article
Citation:: Biomacromolecules, 2016, 17 (3), pp. 1170 - 1178
Issue Date:: 2016-03-14

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Field	Value	Language
dc.contributor.author	Wong, EHH	en_US
dc.contributor.author	Khin, MM	en_US
dc.contributor.author	Ravikumar, V	en_US
dc.contributor.author	Si, Z	en_US
dc.contributor.author	Rice, SA https://orcid.org/0000-0002-9486-2343	en_US
dc.contributor.author	Chan-Park, MB	en_US
dc.date.issued	2016-03-14	en_US
dc.identifier.citation	Biomacromolecules, 2016, 17 (3), pp. 1170 - 1178	en_US
dc.identifier.issn	1525-7797	en_US
dc.identifier.uri	http://hdl.handle.net/10453/101729
dc.description.abstract	© 2016 American Chemical Society. The development of novel reagents and antibiotics for combating multidrug resistance bacteria has received significant attention in recent years. In this study, new antimicrobial star polymers (14-26 nm in diameter) that consist of mixtures of polylysine and glycopolymer arms were developed and were shown to possess antimicrobial efficacy toward Gram positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) (with MIC values as low as 16 μ mL-1) while being non-hemolytic (HC50 > 10 000 μ mL-1) and exhibit excellent mammalian cell biocompatibility. Structure function analysis indicated that the antimicrobial activity and mammalian cell biocompatibility of the star nanoparticles could be optimized by modifying the molar ratio of polylysine to glycopolymers arms. The technology described herein thus represents an innovative approach that could be used to fight deadly infectious diseases.	en_US
dc.relation.ispartof	Biomacromolecules	en_US
dc.relation.isbasedon	10.1021/acs.biomac.5b01766	en_US
dc.subject.classification	Polymers	en_US
dc.subject.mesh	Erythrocytes	en_US
dc.subject.mesh	Cells, Cultured	en_US
dc.subject.mesh	Cell Line	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Enterococcus	en_US
dc.subject.mesh	Hemolysis	en_US
dc.subject.mesh	Glucosamine	en_US
dc.subject.mesh	Polylysine	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Nanoparticles	en_US
dc.subject.mesh	Methicillin-Resistant Staphylococcus aureus	en_US
dc.title	Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	17	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	17	en_US

Abstract:

© 2016 American Chemical Society. The development of novel reagents and antibiotics for combating multidrug resistance bacteria has received significant attention in recent years. In this study, new antimicrobial star polymers (14-26 nm in diameter) that consist of mixtures of polylysine and glycopolymer arms were developed and were shown to possess antimicrobial efficacy toward Gram positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) (with MIC values as low as 16 μ mL-1) while being non-hemolytic (HC50 > 10 000 μ mL-1) and exhibit excellent mammalian cell biocompatibility. Structure function analysis indicated that the antimicrobial activity and mammalian cell biocompatibility of the star nanoparticles could be optimized by modifying the molar ratio of polylysine to glycopolymers arms. The technology described herein thus represents an innovative approach that could be used to fight deadly infectious diseases.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/101729