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Burning the Candle at Both Ends: Have Exoribonucleases Driven Divergence of Regulatory RNA Mechanisms in Bacteria?

Mediati, DG Lalaouna, D Tree, JJ

Regulatory RNAs have emerged as ubiquitous gene regulators in all bacterial species studied to date. The combination of sequence-specific RNA interactions and malleable RNA structure has allowed re...

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RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3'UTR required for intermediate vancomycin resistance.

Mediati, DG Wong, JL Gao, W McKellar, S Pang, CNI Wu, S Wu, W Sy, B Monk, IR Biazik, JM Wilkins, MR Howden, BP Stinear, TP Granneman, S Tree, JJ

Treatment of methicillin-resistant Staphylococcus aureus infections is dependent on the efficacy of last-line antibiotics including vancomycin. Treatment failure is commonly linked to isolates with...

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Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA.

Davies, MR Keller, N Brouwer, S Jespersen, MG Cork, AJ Hayes, AJ Pitt, ME De Oliveira, DMP Harbison-Price, N Bertolla, OM Mediati, DG Curren, BF Taiaroa, G Lacey, JA Smith, HV Fang, N-X Coin, LJM Stevens, K Tong, SYC Sanderson-Smith, M Tree, JJ Irwin, AD Grimwood, K Howden, BP Jennison, AV Walker, MJ

A new variant of Streptococcus pyogenes serotype M1 (designated 'M1UK') has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, a...

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The 3' UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions.

Mediati, DG Dan, W Lalaouna, D Dinh, H Pokhrel, A Rowell, KN Michie, KA Stinear, TP Cain, AK Tree, JJ

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are alarmingly common, and treatment is confined to last-line antibiotics. Vancomycin is the treatment of choice for MRSA bac...

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MERITS: a web-based integrated Mycobacterial PE/PPE protein database.

He, Z Wang, C Guo, X Sun, H Bi, Y Pitt, ME Li, C Song, J Coin, LJM Li, F

MOTIVATION: PE/PPE proteins, highly abundant in the Mycobacterium genome, play a vital role in virulence and immune modulation. Understanding their functions is key to comprehending the internal me...

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Whole-genome duplication in an algal symbiont bolsters coral heat tolerance.

Dougan, KE Bellantuono, AJ Kahlke, T Abbriano, RM Chen, Y Shah, S Granados-Cifuentes, C van Oppen, MJH Bhattacharya, D Suggett, DJ Rodriguez-Lanetty, M Chan, CX

The algal endosymbiont Durusdinium trenchii enhances the resilience of coral reefs under thermal stress. D. trenchii can live freely or in endosymbiosis, and the analysis of genetic markers suggest...

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Multispecies bacterial invasion of human host cells.

Abell-King, C Pokhrel, A Rice, SA Duggin, IG Söderström, B

Urinary tract infection (UTI), one of the most common bacterial infections worldwide, is a typical example of an infection that is often polymicrobial in nature. While the overall infection course ...

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Ultrastructural insights into cellular organization, energy storage and ribosomal dynamics of an ammonia-oxidizing archaeon from oligotrophic oceans.

Zhou, Y Yan, A Yang, J He, W Guo, S Li, Y Wu, J Dai, Y Pan, X Cui, D Pereira, O Teng, W Bi, R Chen, S Fan, L Wang, P Liao, Y Qin, W Sui, S-F Zhu, Y Zhang, C Liu, Z

INTRODUCTION: Nitrososphaeria, formerly known as Thaumarchaeota, constitute a diverse and widespread group of ammonia-oxidizing archaea (AOA) inhabiting ubiquitously in marine and terrestrial envir...

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Algal symbiont diversity in Acropora muricata from the extreme reef of Bouraké associated with resistance to coral bleaching.

Alessi, C Lemonnier, H Camp, EF Wabete, N Payri, C Rodolfo Metalpa, R

Widespread coral bleaching has generally been linked to high water temperatures at larger geographic scales. However, the bleaching response can be highly variable among individual of the same spec...

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Extracellular vesicle formation in Euryarchaeota is driven by a small GTPase.

Mills, J Gebhard, LJ Schubotz, F Shevchenko, A Speth, DR Liao, Y Duggin, IG Marchfelder, A Erdmann, S

Since their discovery, extracellular vesicles (EVs) have changed our view on how organisms interact with their extracellular world. EVs are able to traffic a diverse array of molecules across diffe...

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