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AORI-HAP: a multidimensional risk index to predict in-hospital adverse outcomes in asthma exacerbations.

Yuan, L Zhao, C Wang, L Zhang, L Liu, Y Liu, L Feng, M Melén, E Wang, G Zhang, S Yuan, Y Wang, Q Li, Y Kang, D Zhang, X

BACKGROUND: Despite therapeutic advancements, asthma exacerbations (AEs) remain a major clinical challenge, with immune-inflammatory patterns incompletely characterized. Current guidelines lack rob...

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Indigenous peoples’ voices and engagement on climate change: towards improved health and wellbeing

Lansbury, N Mosby, V Creamer, SJ Moggridge, B Evans, GR Pecl, G Ireland, L

Western climate science largely fails to value, engage with and apply Indigenous Knowledges in a meaningful way. Here, we explore the ways in which the current gap in Indigenous Knowledges and repr...

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Prior exposure strongly influences mechanisms underpinning survival of heat shock in Escherichia coli

Yasir, M Turner, AK Bastkowski, S Jarvis, CS Sweet, R Truong, M Charles, IG Webber, MA

The heat shock response of i Escherichia coli /i represents a canonical example of how bacteria can recognize a stress and invoke a protective response by altering specific gene regulation. However...

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Applications of halophilic enzymes in the pharmaceutical industry and medicine

Velankar, R Shinde, V Kothari, M Gunjal, A

Halophiles are an important group of microorganisms that can grow under high salt conditions. The paper here describes the enzymes of halophiles and their mode of action. The application of halophi...

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Noninvasive Assessment of Urinary Exfoliated Proximal Tubule Cell Multispectral Autofluorescence May Differentiate between Causes of Kidney Transplant Dysfunction.

Wu, HHL Lang, Y Handley, S Knab, A Agha, A Tian, Y Bhargava, A Goldys, EM Pollock, CA Saad, S

KEY POINTS: There is an unmet critical need currently for a noninvasive approach to accurately diagnose the cause of kidney transplant complications. Cell multispectral autofluorescence signals hav...

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Urinary proteomic profiling to identify early biomarkers of non-diabetic chronic kidney disease.

Wu, HHL Parthiban, NK Zenaidee, MA Pang, I Wu, Y Ahn, SB Walker, RJ Pollock, CA Saad, S

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SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome.

Tillett, BJ Dwiyanto, J Secombe, KR George, T Zhang, V Anderson, D Duggan, E Giri, R Loo, D Stoll, T Morrison, M Begun, J Hill, MM Gurzov, EN Bell, KJ Saad, S Barlow, CK Creek, DJ Chong, CW Mariño, E Hamilton-Williams, EE

Type 1 diabetes (T1D) is linked to an altered gut microbiota characterized by reduced short-chain fatty acid (SCFA) production. Oral delivery of a SCFA-yielding biotherapy in adults with T1D was fo...

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Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice.

Manning, JA Jesudason, S Moretti, PAB Pitson, SM Chou, ASY Shabbar, M Saad, S Pollock, C Kumar, S

NEDD4-2, a ubiquitin ligase, regulates a number of ion channels and transporters by promoting their ubiquitination, internalisation and degradation, thereby affecting many signalling and physiologi...

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Hydrogeology, European colonialism, local communities and First Peoples: moving beyond business as usual

Bourke, SA Taucare, M Devoie, É Hansen, C N. Wright, S Shanafield, M Re, V Kagawa-Viviani, A Kenny, A Bell, G Diene, M Kreamer, DK Gurmessa, SK Mulligan, B Sarris, TS Cuthbert, MO Wallis, KJ Moggridge, B

European colonialism altered the connections between First Peoples, local communities, and groundwater systems across the world. In many countries, the practice of hydrogeology remains intertwined ...

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Quantitative metagenomics for marine prokaryotes and photosynthetic eukaryotes.

Bei, Q Williams, NLR Furtado, LE Blasi, DD Williams, J Brotas, V Tarran, G Rees, AP Bowler, C Fuhrman, JA

High-throughput sequencing has provided unprecedented insights into microbial biodiversity in marine and other ecosystems. However, most sequencing-based studies report only relative (compositional...

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