Testing Hardy-Weinberg equilibrium with a simple root-mean-square statistic

Publication Type:
Journal Article
Biostatistics, 2014, 15 (1), pp. 74 - 86
Issue Date:
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We provide evidence that, in certain circumstances, a root-mean-square test of goodness of fit can be significantly more powerful than state-of-the-art tests in detecting deviations from Hardy-Weinberg equilibrium. Unlike Pearson's χ2 test, the log-likelihood-ratio test, and Fisher's exact test, which are sensitive to relative discrepancies between genotypic frequencies, the root-mean-square test is sensitive to absolute discrepancies. This can increase statistical power, as we demonstrate using benchmark data sets and simulations, and through asymptotic analysis. © 2013 The Author 2013. Published by Oxford University Press.
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