Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates

Ramaswamy, W; Ben-Nissan, B; Roest, R; Haynes, D; Zreiqat, H

Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates

Ramaswamy, W Ben-Nissan, B Roest, R Haynes, D Zreiqat, H

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Publication Type:: Journal Article
Citation:: Key Engineering Materials, 2006, 309-311 I pp. 709 - 712
Issue Date:: 2006-04-06

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Field	Value	Language
dc.contributor.author	Ramaswamy, W	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Roest, R	en_US
dc.contributor.author	Haynes, D	en_US
dc.contributor.author	Zreiqat, H	en_US
dc.date.issued	2006-04-06	en_US
dc.identifier.citation	Key Engineering Materials, 2006, 309-311 I pp. 709 - 712	en_US
dc.identifier.issn	1013-9826	en_US
dc.identifier.uri	http://hdl.handle.net/10453/1140
dc.description.abstract	Titanium alloy has been used as a material for orthopaedic implants, however drawbacks still exist. Considerable efforts have been taken to modify the surface structure of the implant material and improve the biological performance. Previously we have demonstrated that biomaterials surface modification has a significant effect on the regulation of osteogenesis. We have investigated the behaviour of human osteoclasts on sol-gel coated carbonated hydroxyapatite on anodized titanium alloy. Osteoclasts cultured on the modified surface were able to attach and spread, exhibiting the characteristic peripheral brush border. Successful differentiation of the monocytes into osteoclasts and their attachment to the coated surface and the formation of resorption-like imprints indicated that carbonate hydroxyapatite (CHAP) coated titanium alloy play a significant role in regulating the functional activity of osteoclasts.	en_US
dc.relation.ispartof	Key Engineering Materials	en_US
dc.subject.classification	Materials	en_US
dc.title	Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates	en_US
dc.type	Journal Article
utslib.citation.volume	309-311 I	en_US
utslib.for	0999 Other Engineering	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	309-311 I	en_US

Abstract:

Titanium alloy has been used as a material for orthopaedic implants, however drawbacks still exist. Considerable efforts have been taken to modify the surface structure of the implant material and improve the biological performance. Previously we have demonstrated that biomaterials surface modification has a significant effect on the regulation of osteogenesis. We have investigated the behaviour of human osteoclasts on sol-gel coated carbonated hydroxyapatite on anodized titanium alloy. Osteoclasts cultured on the modified surface were able to attach and spread, exhibiting the characteristic peripheral brush border. Successful differentiation of the monocytes into osteoclasts and their attachment to the coated surface and the formation of resorption-like imprints indicated that carbonate hydroxyapatite (CHAP) coated titanium alloy play a significant role in regulating the functional activity of osteoclasts.

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http://hdl.handle.net/10453/1140