Observation of infiltration and activation of dendritic cells in primary foci of prostate cancer using fuzhengyiliufa integrative treatments
- Publication Type:
- Journal Article
- Journal of the Australian Traditional-Medicine Society, 2012, 18 (3), pp. 151 - 154
- Issue Date:
Objective: To elucidate the effect of the integrative TCM treatment fuzhengyiliufa on the infiltration and activation of dendritic cells in the primary foci of prostate cancer. Method: A prospective controlled trial of 57 prostate cancer inpatients were recruited for the study. The subjects were divided into two groups. Group 1: 18 subjects were recruited for the study. Ten were randomly assigned to the therapeutic group and eight to the control group. The therapeutic group received the fuzhengyiliufa integrative treatment, which consisted of ingesting the Chinese herbal medicine fuzhengyiliufa combined with routine incretion (endocrine) therapy; the control group received routine incretion therapy only. The remaining 39 patients formed the second group. The second group was also divided into two groups groups according to whether patients received fuzhengyiliufa TCM treatment or not before their biopsy. The TCM group consisted of 19 patients who received fuzhengyiliufa treatments; the control group (20 patients) received no treatment. For statistical analysis the software SPSS13.0 was used. Venue: Guangdong Women's and Children's Hospital and Guangdong Provincial Hospital of Chinese Medicine. Results: Group 1: All 18 patients had returned two pathological samples before the trial. In the therapeutic subgroup of ten patients, in one sample before treatment both CD1a and CD83 were negative. The quantity of CD1a positive dendritic cells after treatment in both groups were elevated compared to the quantity of CD1a before treatments; the differences were statistically significant (p<0.05). The quantity of CD83 positive dendritic cells were higher than pre-treatment levels, with a a statistically significant difference (p<0.05). Group 2: The second group of 39 patients had each returned one pathological sample. The quantity of CD1a with positive dendritic cells in the therapeutic group was higher than that in the control group, with a statistically significant difference of p<0.05). The quantity of CD83 with positive dendritic cells in the therapeutic group was higher than that in of the control group, with a statistically significant difference of p<0.05. Conclusion: Infiltrated and activated dendritic cells in the primary foci of prostate cancer are inhibited. The application of fuzhengyiliuafa integrative treatment increases the number of dendritic cells in the primary foci, thereby greatly enhancing their activation. It can be seen from the study that both the quantity and activation of dendritic cells in prostate cancer foci were reinforced by the integrative use of Chinese herbal medicine and incretion therapy. The combination of herbal decoctions and herbal injections was shown to be more effective than these treatments used separately. It was also observed that when the quantity and activation of dendritic cells were increased infiltration of local lymphocytes became more concentrated. A possible mechanism of this process is that activating dendrite cells causes tumor antigens to activate T lymphocytes, leading to their proliferation and expansion. In this way specific immunity could have been initiated.
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