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Sexual reproduction and genetic polymorphism within the cosmopolitan marine diatom Pseudo-nitzschia pungens.

Kim JH Ajani P Murray SA Kim J-H Lim HC Teng ST Lim PT Han M-S Park BS

Different clades belonging to the cosmopolitan marine diatom Pseudo-nitzschia pungens appear to be present in different oceanic environments, however, a 'hybrid zone', where populations of differen...

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Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria.

Santucci P Johansen MD Point V Poncin I Viljoen A Cavalier J-F Kremer L Canaan S

Mycobacteria share with other actinomycetes the ability to produce large quantities of triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known as lipid droplet...

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Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.

Hatoum D Haddadi N Lin Y Nassif NT McGowan EM

The various sphingosine kinase (SphK) isoenzymes (isozymes) and isoforms, key players in normal cellular physiology, are strongly implicated in cancer and other diseases. Mutations in SphKs, that m...

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Perspectives for Glyco-Engineering of Recombinant Biopharmaceuticals from Microalgae.

Barolo L Abbriano RM Commault AS George J Kahlke T Fabris M Padula MP Lopez A Ralph PJ Pernice M

Microalgae exhibit great potential for recombinant therapeutic protein production, due to lower production costs, immunity to human pathogens, and advanced genetic toolkits. However, a fundamental ...

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The pharmacogenomics of inhaled corticosteroids and lung function decline in COPD.

Obeidat M Faiz A Li X van den Berge M Hansel NN Joubert P Hao K Brandsma C-A Rafaels N Mathias R Ruczinski I Beaty TH Barnes KC Man SFP Paré PD Sin DD

Inhaled corticosteroids (ICS) are widely prescribed for patients with chronic obstructive pulmonary disease (COPD), yet have variable outcomes and adverse reactions, which may be genetically determ...

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Evidence from a mouse model on the dangers of thirdhand electronic cigarette exposure during early life

Chen, H Li, G Allam, VSRR Wang, B Chan, YL Scarfo, C Ueland, M Shimmon, R Fu, S Foster, P Oliver, BG

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An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence.

Lee, C-H Kang, TH Godon, O Watanabe, M Delidakis, G Gillis, CM Sterlin, D Hardy, D Cogné, M Macdonald, LE Murphy, AJ Tu, N Lee, J McDaniel, JR Makowski, E Tessier, PM Meyer, AS Bruhns, P Georgiou, G

The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human neonatal Fc receptor (hFcRn). Engineered Fc...

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Relationships between forced oscillatory impedance and 6-minute walk distance after pulmonary rehabilitation in COPD

Zimmermann, SC Thamrin, C Chan, ASL Bertolin, A Chapman, DG King, GG

© 2020 Zimmermann et al. Rationale: Pulmonary rehabilitation for chronic obstructive pulmonary disease (COPD) reduces dyspnoea and improves exercise capacity and quality of life. The improvement in...

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Assessing impacts of climate change and human activities on streamflow and sediment discharge in the Ganjiang River basin (1964-2013)

Guo, LP Mu, XM Hu, JM Gao, P Zhang, YF Liao, KT Bai, H Chen, XL Song, YJ Jin, N Yu, Q

© 2019 by the authors. National large-scale soil and water conservation controls on the Gangjiang River basin have been documented, but the effect of governance on regional watershed hydrology and ...

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SAT-129 GROUP 2 INNATE LYMPHOID CELLS ARE REDUNDANT IN EXPERIMENTAL RENAL ISCHEMIA-REPERFUSION INJURY

CAMERON, G Loering, S Deshpande, A Jiang, S Molofsky, A McKenzie, A Hansbro, P Starkey, M

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