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Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls.

Kruk, D Yeung, ACY Faiz, A Ten Hacken, NHT Timens, W van Kuppevelt, TH Daamen, W Hof, D Harmsen, MC Rojas, M Heijink, IH

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal c...

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Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms.

Kole, TM Pouwels, SD Bults, R Ketelaar, ME Guryev, V Koll, L Kerstjens, HAM Nawijn, MC Faiz, A van den Berge, M

Studying the effects of asthma SNPs on alternative splicing can lead to new insights into asthma pathophysiology. More specifically, a 17q12 SNP is associated to alternative splicing of GSDMB. http...

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Impact of changes in human airway epithelial cellular composition and differentiation on SARS-CoV-2 infection biology.

Thaler, M Wang, Y van der Does, AM Faiz, A Ninaber, DK Ogando, NS Beckert, H Taube, C Salgado-Benvindo, C Snijder, EJ Bredenbeek, PJ Hiemstra, PS van Hemert, MJ

The consequences of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can range from asymptomatic to fatal disease. Variations in epithelial susceptibility to SARS-CoV-2 i...

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Transcriptomic Comparison of Human Peripartum and Dilated Cardiomyopathy Identifies Differences in Key Disease Pathways.

Taylor, J Yeung, ACY Ashton, A Faiz, A Guryev, V Fang, B Lal, S Grosser, M Dos Remedios, CG Braet, F McLachlan, CS Li, A

Peripartum cardiomyopathy (PPCM) is a rare form of acute onset heart failure that presents in otherwise healthy pregnant women around the time of delivery. While most of these women respond to earl...

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Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD.

Faiz, A Pavlidis, S Kuo, C-H Rowe, A Hiemstra, PS Timens, W Berg, M Wisman, M Guo, Y-K Djukanović, R Sterk, P Meyer, KB Nawijn, MC Adcock, I Chung, KF van den Berge, M

RATIONALE: Severe asthma and chronic obstructive pulmonary disease (COPD) share common pathophysiological traits such as relative corticosteroid insensitivity. We recently published three transcrip...

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An integrated cell atlas of the lung in health and disease.

Sikkema, L Ramírez-Suástegui, C Strobl, DC Gillett, TE Zappia, L Madissoon, E Markov, NS Zaragosi, L-E Ji, Y Ansari, M Arguel, M-J Apperloo, L Banchero, M Bécavin, C Berg, M Chichelnitskiy, E Chung, M-I Collin, A Gay, ACA Gote-Schniering, J Hooshiar Kashani, B Inecik, K Jain, M Kapellos, TS Kole, TM Leroy, S Mayr, CH Oliver, AJ von Papen, M Peter, L Taylor, CJ Walzthoeni, T Xu, C Bui, LT De Donno, C Dony, L Faiz, A Guo, M Gutierrez, AJ Heumos, L Huang, N Ibarra, IL Jackson, ND Kadur Lakshminarasimha Murthy, P Lotfollahi, M Tabib, T Talavera-López, C Travaglini, KJ Wilbrey-Clark, A Worlock, KB Yoshida, M Lung Biological Network Consortium, van den Berge, M Bossé, Y Desai, TJ Eickelberg, O Kaminski, N Krasnow, MA Lafyatis, R Nikolic, MZ Powell, JE Rajagopal, J Rojas, M Rozenblatt-Rosen, O Seibold, MA Sheppard, D Shepherd, DP Sin, DD Timens, W Tsankov, AM Whitsett, J Xu, Y Banovich, NE Barbry, P Duong, TE Falk, CS Meyer, KB Kropski, JA Pe'er, D Schiller, HB Tata, PR Schultze, JL Teichmann, SA Misharin, AV Nawijn, MC Luecken, MD Theis, FJ

Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many ...

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Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium.

Pouwels, SD van den Berge, M Vasse, GF Timens, W Brandsma, C-A Aliee, H Hiemstra, PS Guryev, V Faiz, A

After more than two years the COVID-19 pandemic, that is caused by infection with the respiratory SARS-CoV-2 virus, is still ongoing. The risk to develop severe COVID-19 upon SARS-CoV-2 infection i...

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Twitter trends in #Parasitology determined by text mining and topic modelling.

Ellis, JT Reichel, MP

This study investigated the emergence and use of Twitter, as of July 2023 being rebranded as X, as the main forum for social media communication in parasitology. A dataset of tweets was constructed...

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Acute cigarette smoke exposure leads to higher viral infection in human bronchial epithelial cultures by altering interferon, glycolysis and GDF15-related pathways.

Wang, Y Ninaber, DK Faiz, A van der Linden, AC van Schadewijk, A Lutter, R Hiemstra, PS van der Does, AM Ravi, A

BACKGROUND: Acute exacerbations of chronic inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), are frequently associated with rhinovirus (RV) infections. Despite these...

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Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms.

Mendes de Almeida, V Engel, DF Ricci, MF Cruz, CS Lopes, ÍS Alves, DA d' Auriol, M Magalhães, J Machado, EC Rocha, VM Carvalho, TG Lacerda, LSB Pimenta, JC Aganetti, M Zuccoli, GS Smith, BJ Carregari, VC da Silva Rosa, E Galvão, I Dantas Cassali, G Garcia, CC Teixeira, MM André, LC Ribeiro, FM Martins, FS Saia, RS Costa, VV Martins-de-Souza, D Hansbro, PM Marques, JT Aguiar, ERGR Vieira, AT

Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which...

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