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Airway smooth muscle tone increases airway responsiveness in healthy young adults.

Gazzola, M Lortie, K Henry, C Mailhot-Larouche, S Chapman, DG Couture, C Seow, CY Paré, PD King, GG Boulet, L-P Bossé, Y

Force adaptation, a process whereby sustained spasmogenic activation (viz., tone) of airway smooth muscle (ASM) increases its contractile capacity, has been reported in isolated ASM tissues in vitr...

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Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo.

Stayte, S Rentsch, P Tröscher, AR Bamberger, M Li, KM Vissel, B

Parkinson's disease is a chronic neurodegenerative disease characterized by a significant loss of dopaminergic neurons within the substantia nigra pars compacta region and a subsequent loss of dopa...

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Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats

Tan, Y Kim, J Cheng, J Ong, M Lao, W-G Jin, X-L Lin, Y-G Xiao, L Zhu, X-Q Qu, X-Q

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Traditional ‘maavee’ rice production in Sri Lanka: environmental, economic and social pressures revealed through stakeholder interviews

Horgan, FG Kudavidanage, EP Weragodaarachchi, A Ramp, D

The Nilwala Ganga Basin of Sri Lanka includes important natural wetlands that are habitat for vulnerable animal and plant species. Flood protection and intensive rice production in the Basin have r...

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Differences in the Cellular Response to Acute Spinal Cord Injury between Developing and Mature Rats Highlights the Potential Significance of the Inflammatory Response.

Sutherland, TC Mathews, KJ Mao, Y Nguyen, T Gorrie, CA

There exists a trend for a better functional recovery from spinal cord injury (SCI) in younger patients compared to adults, which is also reported for animal studies; however, the reasons for this ...

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Apoptosis is induced in Chlamydia trachomatis-infected HEp-2 cells by the addition of a combination innate immune activation compounds and the inhibitor wedelolactone.

Huston, WM Gloeckl, S de Boer, L Beagley, KW Timms, P

PROBLEM: Innate immune activation of human cells, for some intracellular pathogens, is advantageous for vacuole morphology and pathogenic viability. It is unknown whether innate immune activation i...

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Serotonin availability in rat colon is reduced during a Western diet model of obesity.

Bertrand, RL Senadheera, S Tanoto, A Tan, KL Howitt, L Chen, H Murphy, TV Sandow, SL Liu, L Bertrand, PP

Constipation and slowed transit are associated with diet-induced obesity, although the mechanisms by which this occurs are unclear. Enterochromaffin (EC) cells within the intestinal epithelium resp...

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A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.

Beham, AW Puellmann, K Laird, R Fuchs, T Streich, R Breysach, C Raddatz, D Oniga, S Peccerella, T Findeisen, P Kzhyshkowska, J Gratchev, A Schweyer, S Saunders, B Wessels, JT Möbius, W Keane, J Becker, H Ganser, A Neumaier, M Kaminski, WE

Macrophages play a central role in host defense against mycobacterial infection and anti- TNF therapy is associated with granuloma disorganization and reactivation of tuberculosis in humans. Here, ...

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Intramacrophage survival of uropathogenic Escherichia coli: differences between diverse clinical isolates and between mouse and human macrophages.

Bokil, NJ Totsika, M Carey, AJ Stacey, KJ Hancock, V Saunders, BM Ravasi, T Ulett, GC Schembri, MA Sweet, MJ

Uropathogenic E. coli (UPEC) are the primary cause of urinary tract infections. Recent studies have demonstrated that UPEC can invade and replicate within epithelial cells, suggesting that this bac...

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Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection.

Stanley, AC de Labastida Rivera, F Haque, A Sheel, M Zhou, Y Amante, FH Bunn, PT Randall, LM Pfeffer, K Scheu, S Hickey, MJ Saunders, BM Ware, C Hill, GR Tamada, K Kaye, PM Engwerda, CR

LIGHT (TNFSF14) is a member of the TNF superfamily involved in inflammation and defence against infection. LIGHT signals via two cell-bound receptors; herpes virus entry mediator (HVEM) and lymphot...

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