A single nucleotide polymorphism in EXO1 gene is associated with cervical cancer susceptibility in chinese patients

Luo, X; Hong, XS; Xiong, XD; Zeng, LQ; Lim, CED

A single nucleotide polymorphism in EXO1 gene is associated with cervical cancer susceptibility in chinese patients

Luo, X Hong, XS Xiong, XD Zeng, LQ Lim, CED

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Publication Type:: Journal Article
Citation:: International Journal of Gynecological Cancer, 2012, 22 (2), pp. 220 - 225
Issue Date:: 2012-02-01

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Field	Value	Language
dc.contributor.author	Luo, X	en_US
dc.contributor.author	Hong, XS	en_US
dc.contributor.author	Xiong, XD	en_US
dc.contributor.author	Zeng, LQ	en_US
dc.contributor.author	Lim, CED	en_US
dc.date.issued	2012-02-01	en_US
dc.identifier.citation	International Journal of Gynecological Cancer, 2012, 22 (2), pp. 220 - 225	en_US
dc.identifier.issn	1048-891X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/114125
dc.description.abstract	Objective: The aim of this study was to investigate the association of Exonuclease1 (EXO1) genetic polymorphism and the development of cervical carcinoma. Methods: This study was conducted with 126 patients diagnosed with cervical cancer and 278 people with no cancer history. The polymerase chain reaction-based restriction fragment length polymorphism was used to evaluate the K589E and C908G gene polymorphisms. Unconditional logistic regression analysis was used to estimate the association between the genotypes and the risk for cervical cancer. Results: This is the first study on the role of EXO1 K589E (rs1047840) and EXO1 C908G (rs10802996) polymorphisms in cervical cancer in a Chinese population. Our results indicated that the EXO1 K589G polymorphism were significantly associated with the risk for cervical cancer. Compared with the G allele EXO1 K589E, the A allele increased the risk for cervical cancer (adjusted odds ratio, 1.67; 95% confidence interval, 1.13-2.45). By contrast, we have not found a significant association between the EXO1 C908G polymorphism and cervical cancer risk (P = 0.791). Conclusion: These findings indicate that the SNPs of EXO1 K589E may contribute to cervical cancer carcinogenesis in Chinese populations. A larger population study will need to be carried out to further validate the potential association of EXO1 genetic polymorphism and cervical carcinoma. Copyright © 2012 by IGCS and ESGO.	en_US
dc.relation.ispartof	International Journal of Gynecological Cancer	en_US
dc.relation.isbasedon	10.1097/IGC.0b013e318234fd8a	en_US
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Carcinoma, Adenosquamous	en_US
dc.subject.mesh	Adenocarcinoma	en_US
dc.subject.mesh	Carcinoma, Squamous Cell	en_US
dc.subject.mesh	Genetic Predisposition to Disease	en_US
dc.subject.mesh	DNA Repair Enzymes	en_US
dc.subject.mesh	Exodeoxyribonucleases	en_US
dc.subject.mesh	DNA Primers	en_US
dc.subject.mesh	Logistic Models	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Polymorphism, Restriction Fragment Length	en_US
dc.subject.mesh	Polymorphism, Single Nucleotide	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Asian Continental Ancestry Group	en_US
dc.subject.mesh	China	en_US
dc.subject.mesh	Uterine Cervical Neoplasms	en_US
dc.subject.mesh	Female	en_US
dc.title	A single nucleotide polymorphism in EXO1 gene is associated with cervical cancer susceptibility in chinese patients	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	22	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

Objective: The aim of this study was to investigate the association of Exonuclease1 (EXO1) genetic polymorphism and the development of cervical carcinoma. Methods: This study was conducted with 126 patients diagnosed with cervical cancer and 278 people with no cancer history. The polymerase chain reaction-based restriction fragment length polymorphism was used to evaluate the K589E and C908G gene polymorphisms. Unconditional logistic regression analysis was used to estimate the association between the genotypes and the risk for cervical cancer. Results: This is the first study on the role of EXO1 K589E (rs1047840) and EXO1 C908G (rs10802996) polymorphisms in cervical cancer in a Chinese population. Our results indicated that the EXO1 K589G polymorphism were significantly associated with the risk for cervical cancer. Compared with the G allele EXO1 K589E, the A allele increased the risk for cervical cancer (adjusted odds ratio, 1.67; 95% confidence interval, 1.13-2.45). By contrast, we have not found a significant association between the EXO1 C908G polymorphism and cervical cancer risk (P = 0.791). Conclusion: These findings indicate that the SNPs of EXO1 K589E may contribute to cervical cancer carcinogenesis in Chinese populations. A larger population study will need to be carried out to further validate the potential association of EXO1 genetic polymorphism and cervical carcinoma. Copyright © 2012 by IGCS and ESGO.

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http://hdl.handle.net/10453/114125