Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates

Zreiqat, H; Roest, R; Valenzuela, S; Milev, A; Ben-Nissan, B

Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates

Zreiqat, H Roest, R

Valenzuela, S

Milev, A Ben-Nissan, B

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Publication Type:: Journal Article
Citation:: Key Engineering Materials, 2005, 284-286 pp. 541 - 544
Issue Date:: 2005-12-01

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Field	Value	Language
dc.contributor.author	Zreiqat, H	en_US
dc.contributor.author	Roest, R https://orcid.org/0000-0002-7018-5472	en_US
dc.contributor.author	Valenzuela, S https://orcid.org/0000-0001-5934-6047	en_US
dc.contributor.author	Milev, A	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.date.issued	2005-12-01	en_US
dc.identifier.citation	Key Engineering Materials, 2005, 284-286 pp. 541 - 544	en_US
dc.identifier.issn	1013-9826	en_US
dc.identifier.uri	http://hdl.handle.net/10453/1146
dc.description.abstract	Poor cell adhesion to orthopaedic and dental implants results in implant failure. Establishing and maintaining mature bone at the bone/device interface is critical to the long-term success of the prostheses. Considerable effort has been devoted to alter the surface characteristics of these biomaterials in order to improve the initial interlocking of device and skeleton in the non-cemented joint prosthesis. Previously we demonstrated that surface chemistry modification of bioceramics induced osteogenesis. In the present work, we investigate the effect of surface chemistry modification of titanium alloy (Ti-6Al-4V) with alkoxide-derived carbonate hydroxyapatite (CHAp) using sol-gel coating methods on human bone derived cell (HBDC) behaviour. Western blotting demonstrated that sol gel coating of Ti-6Al-4V with CHAp upregulated the expression of key signalling protein Shc isoforms (p46, p52, p66) and phosphorylated Erk1/2. CHAp-modification of Ti-6Al-4V is associated with signal transduction pathways involving the key signalling protein She and ERK1/2 which may lead to enhanced gene expression of extracellular matrix proteins at the skeletal tissue/device interface.	en_US
dc.relation.ispartof	Key Engineering Materials	en_US
dc.subject.classification	Materials	en_US
dc.title	Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates	en_US
dc.type	Journal Article
utslib.citation.volume	284-286	en_US
utslib.for	0999 Other Engineering	en_US
utslib.for	09 Engineering	en_US
dc.location.activity	Indianapolis, USA
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	284-286	en_US

Abstract:

Poor cell adhesion to orthopaedic and dental implants results in implant failure. Establishing and maintaining mature bone at the bone/device interface is critical to the long-term success of the prostheses. Considerable effort has been devoted to alter the surface characteristics of these biomaterials in order to improve the initial interlocking of device and skeleton in the non-cemented joint prosthesis. Previously we demonstrated that surface chemistry modification of bioceramics induced osteogenesis. In the present work, we investigate the effect of surface chemistry modification of titanium alloy (Ti-6Al-4V) with alkoxide-derived carbonate hydroxyapatite (CHAp) using sol-gel coating methods on human bone derived cell (HBDC) behaviour. Western blotting demonstrated that sol gel coating of Ti-6Al-4V with CHAp upregulated the expression of key signalling protein Shc isoforms (p46, p52, p66) and phosphorylated Erk1/2. CHAp-modification of Ti-6Al-4V is associated with signal transduction pathways involving the key signalling protein She and ERK1/2 which may lead to enhanced gene expression of extracellular matrix proteins at the skeletal tissue/device interface.

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http://hdl.handle.net/10453/1146