The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.

Publication Type:
Journal Article
Citation:
Antimicrobial agents and chemotherapy, 2012, 56 (6), pp. 3244 - 3249
Issue Date:
2012-06
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Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an ever-increasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria.
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