The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria

Skinner-Adams, TS; Peatey, CL; Anderson, K; Trenholme, KR; Krige, D; Brown, CL; Stack, C; Nsangou, DMM; Mathews, RT; Thivierge, K; Dalton, JP; Gardiner, DL

The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria

Skinner-Adams, TS Peatey, CL Anderson, K Trenholme, KR Krige, D Brown, CL Stack, C Nsangou, DMM Mathews, RT Thivierge, K Dalton, JP Gardiner, DL

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Publication Type:: Journal Article
Citation:: Antimicrobial Agents and Chemotherapy, 2012, 56 (6), pp. 3244 - 3249
Issue Date:: 2012-06-01

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Field	Value	Language
dc.contributor.author	Skinner-Adams, TS	en_US
dc.contributor.author	Peatey, CL	en_US
dc.contributor.author	Anderson, K	en_US
dc.contributor.author	Trenholme, KR	en_US
dc.contributor.author	Krige, D	en_US
dc.contributor.author	Brown, CL	en_US
dc.contributor.author	Stack, C	en_US
dc.contributor.author	Nsangou, DMM	en_US
dc.contributor.author	Mathews, RT	en_US
dc.contributor.author	Thivierge, K	en_US
dc.contributor.author	Dalton, JP	en_US
dc.contributor.author	Gardiner, DL	en_US
dc.date.issued	2012-06-01	en_US
dc.identifier.citation	Antimicrobial Agents and Chemotherapy, 2012, 56 (6), pp. 3244 - 3249	en_US
dc.identifier.issn	0066-4804	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115109
dc.description.abstract	Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an everincreasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria. Copyright © 2012, American Society for Microbiology. All Rights Reserved.	en_US
dc.relation.ispartof	Antimicrobial Agents and Chemotherapy	en_US
dc.relation.isbasedon	10.1128/AAC.06245-11	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice, Inbred C57BL	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Plasmodium falciparum	en_US
dc.subject.mesh	Malaria	en_US
dc.subject.mesh	Aminopeptidases	en_US
dc.subject.mesh	Enzyme Inhibitors	en_US
dc.subject.mesh	Antimalarials	en_US
dc.subject.mesh	Female	en_US
dc.title	The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	56	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1108 Medical Microbiology	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	56	en_US

Abstract:

Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an everincreasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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http://hdl.handle.net/10453/115109