Bone microarchitecture at oral implant sites in ectodermal dysplasia (ED): A comparison between males and females

Silthampitag, P; Klineberg, I; Austin, B; Jones, AS

Bone microarchitecture at oral implant sites in ectodermal dysplasia (ED): A comparison between males and females

Silthampitag, P Klineberg, I Austin, B Jones, AS

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Publication Type:: Journal Article
Citation:: Clinical Oral Implants Research, 2012, 23 (11), pp. 1275 - 1282
Issue Date:: 2012-11-01

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Field	Value	Language
dc.contributor.author	Silthampitag, P	en_US
dc.contributor.author	Klineberg, I	en_US
dc.contributor.author	Austin, B	en_US
dc.contributor.author	Jones, AS https://orcid.org/0000-0002-3522-6371	en_US
dc.date.available	2011-07-15	en_US
dc.date.issued	2012-11-01	en_US
dc.identifier.citation	Clinical Oral Implants Research, 2012, 23 (11), pp. 1275 - 1282	en_US
dc.identifier.issn	0905-7161	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115479
dc.description.abstract	Objective: The aim of this study was to analyse the microarchitecture of bone in association with implant placement in young ectodermal dysplasia (ED) patients. The general hypothesis was that the structural and morphological features of bone microarchitecture are different between males and females, which may influence clinical outcomes. Materials and Methods: The bone harvesting is not additionally invasive, as the procedure was made at the time and site of implant placement. Twenty one samples (8 female, 13 male) were harvested from nine ED participants whose age ranged between 14 and 21 years and specified by the site of harvesting. Micro-CT analysis at 5 μm resolution was conducted on each sample. Specialized CT analysis of the three-dimensional (3-D) bone microstructure was made to compare structural parameters. In addition, two bone samples (one male, one female) were sent to the University of Michigan and analysed at 9 μm resolution. Results: No significant difference was found between male and female samples. Bone analysis of particular sites revealed that bone-specific surface (BS/BV) was found to be significantly higher in male than in female samples, whilst the mean values of 10 parameters, the grey scale value histograms and 3-D visualization showed that female samples had higher compact density than male samples. Conclusion: Microstructural analyses indicated that female ED bone was more compact and with greater trabecular connectedness than male bone. These features may enhance resistance to external force transfer of mastication compared with male bone. Further bone samples from other jaw bone areas will provide information on whether there are regional differences in jawbone quality and quantity, which may influence implant treatment outcomes, as well as follow-up analyses of treatment outcomes. © 2011 John Wiley & Sons A/S.	en_US
dc.relation.ispartof	Clinical Oral Implants Research	en_US
dc.relation.isbasedon	10.1111/j.1600-0501.2011.02303.x	en_US
dc.subject.classification	Dentistry	en_US
dc.subject.mesh	Alveolar Process	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Ectodermal Dysplasia	en_US
dc.subject.mesh	Imaging, Three-Dimensional	en_US
dc.subject.mesh	Dental Implantation, Endosseous	en_US
dc.subject.mesh	Sex Factors	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	X-Ray Microtomography	en_US
dc.subject.mesh	Young Adult	en_US
dc.title	Bone microarchitecture at oral implant sites in ectodermal dysplasia (ED): A comparison between males and females	en_US
dc.type	Journal Article
utslib.citation.volume	11	en_US
utslib.citation.volume	23	en_US
utslib.for	1105 Dentistry	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	11	en_US
pubs.publication-status	Published	en_US
pubs.volume	23	en_US

Abstract:

Objective: The aim of this study was to analyse the microarchitecture of bone in association with implant placement in young ectodermal dysplasia (ED) patients. The general hypothesis was that the structural and morphological features of bone microarchitecture are different between males and females, which may influence clinical outcomes. Materials and Methods: The bone harvesting is not additionally invasive, as the procedure was made at the time and site of implant placement. Twenty one samples (8 female, 13 male) were harvested from nine ED participants whose age ranged between 14 and 21 years and specified by the site of harvesting. Micro-CT analysis at 5 μm resolution was conducted on each sample. Specialized CT analysis of the three-dimensional (3-D) bone microstructure was made to compare structural parameters. In addition, two bone samples (one male, one female) were sent to the University of Michigan and analysed at 9 μm resolution. Results: No significant difference was found between male and female samples. Bone analysis of particular sites revealed that bone-specific surface (BS/BV) was found to be significantly higher in male than in female samples, whilst the mean values of 10 parameters, the grey scale value histograms and 3-D visualization showed that female samples had higher compact density than male samples. Conclusion: Microstructural analyses indicated that female ED bone was more compact and with greater trabecular connectedness than male bone. These features may enhance resistance to external force transfer of mastication compared with male bone. Further bone samples from other jaw bone areas will provide information on whether there are regional differences in jawbone quality and quantity, which may influence implant treatment outcomes, as well as follow-up analyses of treatment outcomes. © 2011 John Wiley & Sons A/S.

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http://hdl.handle.net/10453/115479