Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms

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Journal Article
Angewandte Chemie - International Edition, 2012, 51 (36), pp. 9057 - 9060
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Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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