Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms

Barraud, N; Kardak, BG; Yepuri, NR; Howlin, RP; Webb, JS; Faust, SN; Kjelleberg, S; Rice, SA; Kelso, MJ

Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms

Barraud, N Kardak, BG Yepuri, NR Howlin, RP Webb, JS Faust, SN Kjelleberg, S Rice, SA

Kelso, MJ

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Publication Type:: Journal Article
Citation:: Angewandte Chemie - International Edition, 2012, 51 (36), pp. 9057 - 9060
Issue Date:: 2012-09-03

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Field	Value	Language
dc.contributor.author	Barraud, N	en_US
dc.contributor.author	Kardak, BG	en_US
dc.contributor.author	Yepuri, NR	en_US
dc.contributor.author	Howlin, RP	en_US
dc.contributor.author	Webb, JS	en_US
dc.contributor.author	Faust, SN	en_US
dc.contributor.author	Kjelleberg, S	en_US
dc.contributor.author	Rice, SA https://orcid.org/0000-0002-9486-2343	en_US
dc.contributor.author	Kelso, MJ	en_US
dc.date.issued	2012-09-03	en_US
dc.identifier.citation	Angewandte Chemie - International Edition, 2012, 51 (36), pp. 9057 - 9060	en_US
dc.identifier.issn	1433-7851	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115486
dc.identifier.uri	http://hdl.handle.net/10453/115486
dc.description.abstract	Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.	en_US
dc.relation.ispartof	Angewandte Chemie - International Edition	en_US
dc.relation.isbasedon	10.1002/anie.201202414	en_US
dc.subject.classification	Organic Chemistry	en_US
dc.subject.mesh	Biofilms	en_US
dc.subject.mesh	Pseudomonas aeruginosa	en_US
dc.subject.mesh	Cephalosporins	en_US
dc.subject.mesh	beta-Lactamases	en_US
dc.subject.mesh	Nitric Oxide Donors	en_US
dc.subject.mesh	Prodrugs	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Biofilms	en_US
dc.subject.mesh	Cephalosporins	en_US
dc.subject.mesh	Nitric Oxide Donors	en_US
dc.subject.mesh	Prodrugs	en_US
dc.subject.mesh	Pseudomonas aeruginosa	en_US
dc.subject.mesh	beta-Lactamases	en_US
dc.title	Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms	en_US
dc.type	Journal Article
utslib.description.version	Published	en_US
utslib.citation.volume	36	en_US
utslib.citation.volume	51	en_US
utslib.for	03 Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	36	en_US
pubs.publication-status	Published	en_US
pubs.volume	51	en_US

Abstract:

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/115486