Mechanisms of glucocorticoid action and insensitivity in airways disease

Boardman, C; Chachi, L; Gavrila, A; Keenan, CR; Perry, MM; Xia, YC; Meurs, H; Sharma, P

Mechanisms of glucocorticoid action and insensitivity in airways disease

Boardman, C Chachi, L Gavrila, A Keenan, CR Perry, MM Xia, YC Meurs, H Sharma, P

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Publication Type:: Journal Article
Citation:: Pulmonary Pharmacology and Therapeutics, 2014, 29 (2), pp. 129 - 143
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Boardman, C	en_US
dc.contributor.author	Chachi, L	en_US
dc.contributor.author	Gavrila, A	en_US
dc.contributor.author	Keenan, CR	en_US
dc.contributor.author	Perry, MM	en_US
dc.contributor.author	Xia, YC	en_US
dc.contributor.author	Meurs, H	en_US
dc.contributor.author	Sharma, P https://orcid.org/0000-0002-2904-2306	en_US
dc.date.available	2014-08-25	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Pulmonary Pharmacology and Therapeutics, 2014, 29 (2), pp. 129 - 143	en_US
dc.identifier.issn	1094-5539	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115698
dc.description.abstract	© 2014 Elsevier Ltd. Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases including asthma and chronic obstructive pulmonary disease (COPD). However, it has been recognized that glucocorticoids do not work well in certain patient populations suggesting reduced sensitivity. The ultimate biologic responses to glucocorticoids are determined by not only the concentration of glucocorticoids but also the differences between individuals in glucocorticoid sensitivity, which is influenced by multiple factors. Studies are emerging to understand these mechanisms in detail, which would help in increasing glucocorticoid sensitivity in patients with chronic airways disease. This review aims to highlight both classical and emerging concepts of the anti-inflammatory mechanisms of glucocorticoids and also review some novel strategies to overcome steroid insensitivity in airways disease.	en_US
dc.relation.ispartof	Pulmonary Pharmacology and Therapeutics	en_US
dc.relation.isbasedon	10.1016/j.pupt.2014.08.008	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Respiratory Tract Diseases	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive	en_US
dc.subject.mesh	Receptors, Glucocorticoid	en_US
dc.subject.mesh	Anti-Inflammatory Agents	en_US
dc.subject.mesh	Glucocorticoids	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Signal Transduction	en_US
dc.title	Mechanisms of glucocorticoid action and insensitivity in airways disease	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	29	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	29	en_US

Abstract:

© 2014 Elsevier Ltd. Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases including asthma and chronic obstructive pulmonary disease (COPD). However, it has been recognized that glucocorticoids do not work well in certain patient populations suggesting reduced sensitivity. The ultimate biologic responses to glucocorticoids are determined by not only the concentration of glucocorticoids but also the differences between individuals in glucocorticoid sensitivity, which is influenced by multiple factors. Studies are emerging to understand these mechanisms in detail, which would help in increasing glucocorticoid sensitivity in patients with chronic airways disease. This review aims to highlight both classical and emerging concepts of the anti-inflammatory mechanisms of glucocorticoids and also review some novel strategies to overcome steroid insensitivity in airways disease.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/115698