Tunable lifetime multiplexing using luminescent nanocrystals

Lu, Y; Zhao, J; Zhang, R; Liu, Y; Liu, D; Goldys, EM; Yang, X; Xi, P; Sunna, A; Lu, J; Shi, Y; Leif, RC; Huo, Y; Shen, J; Piper, JA; Robinson, JP; Jin, D

Tunable lifetime multiplexing using luminescent nanocrystals

Lu, Y Zhao, J Zhang, R Liu, Y Liu, D Goldys, EM Yang, X Xi, P Sunna, A Lu, J Shi, Y Leif, RC Huo, Y Shen, J Piper, JA Robinson, JP Jin, D

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Publication Type:: Journal Article
Citation:: Nature Photonics, 2014, 8 (1), pp. 32 - 36
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Lu, Y	en_US
dc.contributor.author	Zhao, J	en_US
dc.contributor.author	Zhang, R	en_US
dc.contributor.author	Liu, Y	en_US
dc.contributor.author	Liu, D	en_US
dc.contributor.author	Goldys, EM	en_US
dc.contributor.author	Yang, X	en_US
dc.contributor.author	Xi, P	en_US
dc.contributor.author	Sunna, A	en_US
dc.contributor.author	Lu, J	en_US
dc.contributor.author	Shi, Y	en_US
dc.contributor.author	Leif, RC	en_US
dc.contributor.author	Huo, Y	en_US
dc.contributor.author	Shen, J	en_US
dc.contributor.author	Piper, JA	en_US
dc.contributor.author	Robinson, JP	en_US
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Nature Photonics, 2014, 8 (1), pp. 32 - 36	en_US
dc.identifier.issn	1749-4885	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115858
dc.description.abstract	Optical multiplexing plays an important role in applications such as optical data storage, document security, molecular probes and bead assays for personalized medicine. Conventional fluorescent colour coding is limited by spectral overlap and background interference, restricting the number of distinguishable identities. Here, we show that tunable luminescent lifetimes τ in the microsecond region can be exploited to code individual upconversion nanocrystals. In a single colour band, one can generate more than ten nanocrystal populations with distinct lifetimes ranging from 25.6 μs to 662.4 μs and decode their well-separated lifetime identities, which are independent of both colour and intensity. Such 'τ-dots' potentially suit multichannel bioimaging, high-throughput cytometry quantification, high-density data storage, as well as security codes to combat counterfeiting. This demonstration extends the optical multiplexing capability by adding the temporal dimension of luminescent signals, opening new opportunities in the life sciences, medicine and data security. © 2013 Macmillan Publishers Limited. All rights reserved.	en_US
dc.relation.ispartof	Nature Photonics	en_US
dc.relation.isbasedon	10.1038/nphoton.2013.322	en_US
dc.subject.classification	Optoelectronics & Photonics	en_US
dc.title	Tunable lifetime multiplexing using luminescent nanocrystals	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	8	en_US
utslib.for	0205 Optical Physics	en_US
utslib.for	01 Mathematical Sciences	en_US
utslib.for	02 Physical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	8	en_US

Abstract:

Optical multiplexing plays an important role in applications such as optical data storage, document security, molecular probes and bead assays for personalized medicine. Conventional fluorescent colour coding is limited by spectral overlap and background interference, restricting the number of distinguishable identities. Here, we show that tunable luminescent lifetimes τ in the microsecond region can be exploited to code individual upconversion nanocrystals. In a single colour band, one can generate more than ten nanocrystal populations with distinct lifetimes ranging from 25.6 μs to 662.4 μs and decode their well-separated lifetime identities, which are independent of both colour and intensity. Such 'τ-dots' potentially suit multichannel bioimaging, high-throughput cytometry quantification, high-density data storage, as well as security codes to combat counterfeiting. This demonstration extends the optical multiplexing capability by adding the temporal dimension of luminescent signals, opening new opportunities in the life sciences, medicine and data security. © 2013 Macmillan Publishers Limited. All rights reserved.

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http://hdl.handle.net/10453/115858