High rates of sexually transmissible infections in HIV-positive patients in the Australian HIV Observational Database: A prospective cohort study

Mulhall, BP; Wright, S; Allen, D; Brown, K; Dickson, B; Grotowski, M; Jackson, E; Petoumenos, K; Read, P; Read, T; Russell, D; Smith, DJ; Templeton, DJ; Fairley, CK; Law, MG

High rates of sexually transmissible infections in HIV-positive patients in the Australian HIV Observational Database: A prospective cohort study

Mulhall, BP Wright, S

Allen, D Brown, K Dickson, B Grotowski, M Jackson, E Petoumenos, K Read, P Read, T Russell, D Smith, DJ Templeton, DJ Fairley, CK Law, MG

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Publication Type:: Journal Article
Citation:: Sexual Health, 2014, 11 (4), pp. 291 - 297
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Mulhall, BP	en_US
dc.contributor.author	Wright, S https://orcid.org/0000-0002-8593-6056	en_US
dc.contributor.author	Allen, D	en_US
dc.contributor.author	Brown, K	en_US
dc.contributor.author	Dickson, B	en_US
dc.contributor.author	Grotowski, M	en_US
dc.contributor.author	Jackson, E	en_US
dc.contributor.author	Petoumenos, K	en_US
dc.contributor.author	Read, P	en_US
dc.contributor.author	Read, T	en_US
dc.contributor.author	Russell, D	en_US
dc.contributor.author	Smith, DJ	en_US
dc.contributor.author	Templeton, DJ	en_US
dc.contributor.author	Fairley, CK	en_US
dc.contributor.author	Law, MG	en_US
dc.date.available	2014-05-19	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Sexual Health, 2014, 11 (4), pp. 291 - 297	en_US
dc.identifier.issn	1448-5028	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115871
dc.description.abstract	© CSIRO 2014. Background In HIV-positive people, sexually transmissible infections (STIs) probably increase the infectiousness of HIV. Methods: In 2010, we established a cohort of individuals (n=554) from clinics in the Australian HIV Observational Database (AHOD). We calculated retrospective rates for four STIs for 2005-10 and prospective incidence rates for 2010-11. Results: At baseline (2010), patient characteristics were similar to the rest of AHOD. Overall incidence was 12.5 per 100 person-years. Chlamydial infections increased from 3.4 per 100 person-years (95% confidence interval (CI): 1.9-5.7) in 2005 to 6.7 per 100 person-years (95% CI: 4.5-9.5) in 2011, peaking in 2010 (8.1 per 100 person-years; 95% CI: 5.6-11.2). Cases were distributed among rectal (61.9%), urethral (34%) and pharyngeal (6.3%) sites. Gonococcal infections increased, peaking in 2010 (4.7 per 100 person-years; 95% CI: 5.6-11.2; Ptrend=0.0099), distributed among rectal (63.9%), urethral (27.9%) and pharyngeal (14.8%) sites. Syphilis showed several peaks, the largest in 2008 (5.3 per 100 person-years; 95% CI: 3.3-8.0); the overall trend was not significant (P=0.113). Genital warts declined from 7.5 per 100 person-years (95% CI: 4.8-11.3) in 2005 to 2.4 per 100 person-years (95% CI: 1.1-4.5) in 2011 (Ptrend=0.0016). Conclusions: For chlamydial and gonococcal infections, incidence was higher than previous Australian estimates among HIV-infected men who have sex with men, increasing during 2005-2011. Rectal infections outnumbered infections at other sites. Syphilis incidence remained high but did not increase; that of genital warts was lower and decreased.	en_US
dc.relation.ispartof	Sexual Health	en_US
dc.relation.isbasedon	10.1071/SH13074	en_US
dc.subject.classification	Public Health	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Chlamydia Infections	en_US
dc.subject.mesh	Gonorrhea	en_US
dc.subject.mesh	Syphilis	en_US
dc.subject.mesh	Sexually Transmitted Diseases	en_US
dc.subject.mesh	Condylomata Acuminata	en_US
dc.subject.mesh	HIV Infections	en_US
dc.subject.mesh	Incidence	en_US
dc.subject.mesh	Retrospective Studies	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Homosexuality, Male	en_US
dc.subject.mesh	Databases, Factual	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Sexual and Gender Minorities	en_US
dc.title	High rates of sexually transmissible infections in HIV-positive patients in the Australian HIV Observational Database: A prospective cohort study	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	11	en_US
utslib.for	0104 Statistics	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	16 Studies in Human Society	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	11	en_US

Abstract:

© CSIRO 2014. Background In HIV-positive people, sexually transmissible infections (STIs) probably increase the infectiousness of HIV. Methods: In 2010, we established a cohort of individuals (n=554) from clinics in the Australian HIV Observational Database (AHOD). We calculated retrospective rates for four STIs for 2005-10 and prospective incidence rates for 2010-11. Results: At baseline (2010), patient characteristics were similar to the rest of AHOD. Overall incidence was 12.5 per 100 person-years. Chlamydial infections increased from 3.4 per 100 person-years (95% confidence interval (CI): 1.9-5.7) in 2005 to 6.7 per 100 person-years (95% CI: 4.5-9.5) in 2011, peaking in 2010 (8.1 per 100 person-years; 95% CI: 5.6-11.2). Cases were distributed among rectal (61.9%), urethral (34%) and pharyngeal (6.3%) sites. Gonococcal infections increased, peaking in 2010 (4.7 per 100 person-years; 95% CI: 5.6-11.2; Ptrend=0.0099), distributed among rectal (63.9%), urethral (27.9%) and pharyngeal (14.8%) sites. Syphilis showed several peaks, the largest in 2008 (5.3 per 100 person-years; 95% CI: 3.3-8.0); the overall trend was not significant (P=0.113). Genital warts declined from 7.5 per 100 person-years (95% CI: 4.8-11.3) in 2005 to 2.4 per 100 person-years (95% CI: 1.1-4.5) in 2011 (Ptrend=0.0016). Conclusions: For chlamydial and gonococcal infections, incidence was higher than previous Australian estimates among HIV-infected men who have sex with men, increasing during 2005-2011. Rectal infections outnumbered infections at other sites. Syphilis incidence remained high but did not increase; that of genital warts was lower and decreased.

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http://hdl.handle.net/10453/115871