Engineering and optimisation of medically multi-functional mesoporous SiO <inf>2</inf> fibers as effective wound dressing material
- Publication Type:
- Journal Article
- Journal of Materials Chemistry, 2011, 21 (26), pp. 9595 - 9602
- Issue Date:
|Engineering and optimisation of medically multi-functional mesoporous SiO2.pdf||Published Version||652.62 kB|
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
In this paper, we propose a novel strategy for the preparation of flexible mesoporous SiO 2 fibers containing silver nanoparticles (Ag-cSiO 2 @mSiO 2 ) as an effective wound dressing. The Ag-cSiO 2 @mSiO 2 was core-shell structured, composed of a condensed electrospun SiO 2 nanofiber doped with Ag NPs (silver nanoparticles) and a mesoporous SiO 2 shell. Due to a high specific surface area and large pore volume, the Ag-cSiO 2 @mSiO 2 can substantially absorb exudates, the absorption capacity for water and SBF (simulated body fluid) reached 267 wt% and 254 wt% of the sample, respectively. Additionally, the mesopores can also act as hosts for the accommodation of drugs. The Loading capacity of IBU (ibuprofen) reached up to 18 wt% of the sample, and its release was relatively fast, more than 85% of the drug was released within 12 h. The condensed core of the SiO 2 nanofiber not only endowed the sample with a high flexibility, but also slowly released silver to possess a sustained antibiotic effect. Considering its effective exudate-absorption ability, dual drug-release profiles (fast release of IBU and sustained release of silver), together with its chemical and physical stability, biocompatibility and high flexibility, Ag-cSiO 2 @mSiO 2 could be a promising wound dressing material. © 2011 The Royal Society of Chemistry.
Please use this identifier to cite or link to this item: