Spider venom peptides as leads for drug and insecticide design

Bosmans, F; Escoubas, P; Nicholson, GM

Spider venom peptides as leads for drug and insecticide design

Bosmans, F Escoubas, P Nicholson, GM

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Publisher:: Editora UFMG
Publication Type:: Chapter
Citation:: Animal Toxins: State of the Art. Perspectives In Health and Biotechnology, 2009, 1, pp. 269 - 290
Issue Date:: 2009-01

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Field	Value	Language
dc.contributor.author	Bosmans, F	en_US
dc.contributor.author	Escoubas, P	en_US
dc.contributor.author	Nicholson, GM https://orcid.org/0000-0002-4277-4296	en_US
dc.contributor.editor	de Lima, ME	en_US
dc.contributor.editor	Pimenta, AMC	en_US
dc.contributor.editor	Martin-Eauclaire, MF	en_US
dc.contributor.editor	Zingali, RB	en_US
dc.contributor.editor	Rochat, H	en_US
dc.date.issued	2009-01	en_US
dc.identifier.citation	Animal Toxins: State of the Art. Perspectives In Health and Biotechnology, 2009, 1, pp. 269 - 290	en_US
dc.identifier.isbn	978-85-7041-735-0	en_US
dc.identifier.uri	http://hdl.handle.net/10453/11657
dc.description.abstract	Spider venoms represent highly complex cocktails of proteins, peptides, neurotransmitters, acylpolyamines and other small molecules employed to subdue and kill their prey or predators. By a process of natural selection, spider venoms have evolved as complex pre-optimized combinatorial peptide libraries, displaying Wide-ranging pharmacological activities.The therapeutic potential of these peptides stems from their highly potent and specific actions to modulate an extensive range of ion channels, receptors, and transporters in vertebrates and invertebrates,as well as their antimicrobial activity. Nevertheless, it is only since the advent of modern analytical technologies that the full potential of this resource is beginning to be exploited for validating novel insecticide targets, and for aiding in the design of novel drugs and bioinsecticides. These techniques have identified that the currently known spider venom pool represents a resource of several million peptides that selectivelytarget specific subtypes ofion channels or receptors. Indeed, some spider toxins are becoming the defining pharmacology for specificsubtypes of ion channels. Furthermore, structure-function studies ofthese molecules are leading not only to the discovery of new molecular tools, but are also providing insight into novel therapeutic approaches for the treatment of cardiovascular diseases, cancer, neuromuscular diseases, pain and to a variety ... of other pathological conditions. Against this background, this review will evaluate peptidic spider toxins as possible lead compounds for new therapeutics and for controlling insect pests. Special attention will be given to their role in the discovery of novel approaches in analgesia and cardiovascular research.	en_US
dc.publisher	Editora UFMG	en_US
dc.relation.ispartof	Animal Toxins: State of the Art. Perspectives In Health and Biotechnology	en_US
dc.title	Spider venom peptides as leads for drug and insecticide design	en_US
dc.type	Chapter
utslib.location	Belo Horizonte	en_US
utslib.for	110999 Neurosciences not elsewhere classified	en_US
utslib.for	111502 Clinical Pharmacology and Therapeutics	en_US
utslib.for	111601 Cell Physiology	en_US
utslib.for	111506 Toxicology (incl. Clinical Toxicology)	en_US
utslib.citation.edition	1	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.consider-herdc	true	en_US
pubs.edition	1	en_US
pubs.place-of-publication	Belo Horizonte	en_US
pubs.publication-status	Published	en_US

Abstract:

Spider venoms represent highly complex cocktails of proteins, peptides, neurotransmitters, acylpolyamines and other small molecules employed to subdue and kill their prey or predators. By a process of natural selection, spider venoms have evolved as complex pre-optimized combinatorial peptide libraries, displaying Wide-ranging pharmacological activities.The therapeutic potential of these peptides stems from their highly potent and specific actions to modulate an extensive range of ion channels, receptors, and transporters in vertebrates and invertebrates,as well as their antimicrobial activity. Nevertheless, it is only since the advent of modern analytical technologies that the full potential of this resource is beginning to be exploited for validating novel insecticide targets, and for aiding in the design of novel drugs and bioinsecticides. These techniques have identified that the currently known spider venom pool represents a resource of several million peptides that selectivelytarget specific subtypes ofion channels or receptors. Indeed, some spider toxins are becoming the defining pharmacology for specificsubtypes of ion channels. Furthermore, structure-function studies ofthese molecules are leading not only to the discovery of new molecular tools, but are also providing insight into novel therapeutic approaches for the treatment of cardiovascular diseases, cancer, neuromuscular diseases, pain and to a variety ... of other pathological conditions. Against this background, this review will evaluate peptidic spider toxins as possible lead compounds for new therapeutics and for controlling insect pests. Special attention will be given to their role in the discovery of novel approaches in analgesia and cardiovascular research.

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http://hdl.handle.net/10453/11657