Influenza A Virus Migration and Persistence in North American Wild Birds

Bahl, J; Krauss, S; Kühnert, D; Fourment, M; Raven, G; Pryor, SP; Niles, LJ; Danner, A; Walker, D; Mendenhall, IH; Su, YCF; Dugan, VG; Halpin, RA; Stockwell, TB; Webby, RJ; Wentworth, DE; Drummond, AJ; Smith, GJD; Webster, RG

Influenza A Virus Migration and Persistence in North American Wild Birds

Bahl, J Krauss, S Kühnert, D Fourment, M

Raven, G Pryor, SP Niles, LJ Danner, A Walker, D Mendenhall, IH Su, YCF Dugan, VG Halpin, RA Stockwell, TB Webby, RJ Wentworth, DE Drummond, AJ Smith, GJD Webster, RG

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Publication Type:: Journal Article
Citation:: PLoS Pathogens, 2013, 9 (8)
Issue Date:: 2013-08-01

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Field	Value	Language
dc.contributor.author	Bahl, J	en_US
dc.contributor.author	Krauss, S	en_US
dc.contributor.author	Kühnert, D	en_US
dc.contributor.author	Fourment, M https://orcid.org/0000-0001-8153-9822	en_US
dc.contributor.author	Raven, G	en_US
dc.contributor.author	Pryor, SP	en_US
dc.contributor.author	Niles, LJ	en_US
dc.contributor.author	Danner, A	en_US
dc.contributor.author	Walker, D	en_US
dc.contributor.author	Mendenhall, IH	en_US
dc.contributor.author	Su, YCF	en_US
dc.contributor.author	Dugan, VG	en_US
dc.contributor.author	Halpin, RA	en_US
dc.contributor.author	Stockwell, TB	en_US
dc.contributor.author	Webby, RJ	en_US
dc.contributor.author	Wentworth, DE	en_US
dc.contributor.author	Drummond, AJ	en_US
dc.contributor.author	Smith, GJD	en_US
dc.contributor.author	Webster, RG	en_US
dc.date.available	2013-06-18	en_US
dc.date.issued	2013-08-01	en_US
dc.identifier.citation	PLoS Pathogens, 2013, 9 (8)	en_US
dc.identifier.issn	1553-7366	en_US
dc.identifier.uri	http://hdl.handle.net/10453/116579
dc.description.abstract	Wild birds have been implicated in the emergence of human and livestock influenza. The successful prediction of viral spread and disease emergence, as well as formulation of preparedness plans have been hampered by a critical lack of knowledge of viral movements between different host populations. The patterns of viral spread and subsequent risk posed by wild bird viruses therefore remain unpredictable. Here we analyze genomic data, including 287 newly sequenced avian influenza A virus (AIV) samples isolated over a 34-year period of continuous systematic surveillance of North American migratory birds. We use a Bayesian statistical framework to test hypotheses of viral migration, population structure and patterns of genetic reassortment. Our results reveal that despite the high prevalence of Charadriiformes infected in Delaware Bay this host population does not appear to significantly contribute to the North American AIV diversity sampled in Anseriformes. In contrast, influenza viruses sampled from Anseriformes in Alberta are representative of the AIV diversity circulating in North American Anseriformes. While AIV may be restricted to specific migratory flyways over short time frames, our large-scale analysis showed that the long-term persistence of AIV was independent of bird flyways with migration between populations throughout North America. Analysis of long-term surveillance data provides vital insights to develop appropriately informed predictive models critical for pandemic preparedness and livestock protection. © 2013 Bahl et al.	en_US
dc.relation.ispartof	PLoS Pathogens	en_US
dc.relation.isbasedon	10.1371/journal.ppat.1003570	en_US
dc.subject.classification	Virology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Influenza A virus	en_US
dc.subject.mesh	Animal Migration	en_US
dc.subject.mesh	Models, Biological	en_US
dc.subject.mesh	North America	en_US
dc.subject.mesh	Charadriiformes	en_US
dc.subject.mesh	Influenza in Birds	en_US
dc.title	Influenza A Virus Migration and Persistence in North American Wild Birds	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	9	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1107 Immunology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	9	en_US

Abstract:

Wild birds have been implicated in the emergence of human and livestock influenza. The successful prediction of viral spread and disease emergence, as well as formulation of preparedness plans have been hampered by a critical lack of knowledge of viral movements between different host populations. The patterns of viral spread and subsequent risk posed by wild bird viruses therefore remain unpredictable. Here we analyze genomic data, including 287 newly sequenced avian influenza A virus (AIV) samples isolated over a 34-year period of continuous systematic surveillance of North American migratory birds. We use a Bayesian statistical framework to test hypotheses of viral migration, population structure and patterns of genetic reassortment. Our results reveal that despite the high prevalence of Charadriiformes infected in Delaware Bay this host population does not appear to significantly contribute to the North American AIV diversity sampled in Anseriformes. In contrast, influenza viruses sampled from Anseriformes in Alberta are representative of the AIV diversity circulating in North American Anseriformes. While AIV may be restricted to specific migratory flyways over short time frames, our large-scale analysis showed that the long-term persistence of AIV was independent of bird flyways with migration between populations throughout North America. Analysis of long-term surveillance data provides vital insights to develop appropriately informed predictive models critical for pandemic preparedness and livestock protection. © 2013 Bahl et al.

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http://hdl.handle.net/10453/116579