The Roles of protein glycation, glycoxidation, and advanced glycation end-product formation in diabetes-induced atherosclerosis

Rashid, I; Brown, BE; Van Reyk, DM; Davies, MJ

The Roles of protein glycation, glycoxidation, and advanced glycation end-product formation in diabetes-induced atherosclerosis

Rashid, I Brown, BE Van Reyk, DM

Davies, MJ

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Publication Type:: Chapter
Citation:: Biochemistry of Atherosclerosis, 2006, pp. 247 - 283
Issue Date:: 2006-12-01

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Field	Value	Language
dc.contributor.author	Rashid, I	en_US
dc.contributor.author	Brown, BE	en_US
dc.contributor.author	Van Reyk, DM https://orcid.org/0000-0002-7768-8662	en_US
dc.contributor.author	Davies, MJ	en_US
dc.date.issued	2006-12-01	en_US
dc.identifier.citation	Biochemistry of Atherosclerosis, 2006, pp. 247 - 283	en_US
dc.identifier.isbn	0387312528	en_US
dc.identifier.isbn	9780387312521	en_US
dc.identifier.uri	http://hdl.handle.net/10453/11659
dc.description.abstract	Diabetes is known to induce a range of micro-and macrovascular complications, with the latter resulting in premature and accelerated atherosclerosis. Thus people with diabetes have a 2-4-fold increased risk of developing cardiovascular diseases which is responsible for ca. 50% of deaths amongst people with diabetes. The mechanisms behind this elevated risk are still not fully understood, though there is now increasing evidence for a role of glycation and glycoxidation reactions induced by hyperglycemia. This article reviews current knowledge of the role that these reactions play in diabetesinduced atherosclerosis with particular emphasis on the molecular reactions that result in the modification of lipoproteins, and the consequences of these reactions on cellular metabolism. © 2006 Springer Science+Business Media, LLC. All rights reserved.	en_US
dc.relation.ispartof	Biochemistry of Atherosclerosis	en_US
dc.relation.isbasedon	10.1007/0-387-36279-3_12	en_US
dc.title	The Roles of protein glycation, glycoxidation, and advanced glycation end-product formation in diabetes-induced atherosclerosis	en_US
dc.type	Chapter
utslib.for	110201 Cardiology (incl. Cardiovascular Diseases)	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US

Abstract:

Diabetes is known to induce a range of micro-and macrovascular complications, with the latter resulting in premature and accelerated atherosclerosis. Thus people with diabetes have a 2-4-fold increased risk of developing cardiovascular diseases which is responsible for ca. 50% of deaths amongst people with diabetes. The mechanisms behind this elevated risk are still not fully understood, though there is now increasing evidence for a role of glycation and glycoxidation reactions induced by hyperglycemia. This article reviews current knowledge of the role that these reactions play in diabetesinduced atherosclerosis with particular emphasis on the molecular reactions that result in the modification of lipoproteins, and the consequences of these reactions on cellular metabolism. © 2006 Springer Science+Business Media, LLC. All rights reserved.

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http://hdl.handle.net/10453/11659