The Roles of protein glycation, glycoxidation, and advanced glycation end-product formation in diabetes-induced atherosclerosis

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Biochemistry of Atherosclerosis, 2006, pp. 247 - 283
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Diabetes is known to induce a range of micro-and macrovascular complications, with the latter resulting in premature and accelerated atherosclerosis. Thus people with diabetes have a 2-4-fold increased risk of developing cardiovascular diseases which is responsible for ca. 50% of deaths amongst people with diabetes. The mechanisms behind this elevated risk are still not fully understood, though there is now increasing evidence for a role of glycation and glycoxidation reactions induced by hyperglycemia. This article reviews current knowledge of the role that these reactions play in diabetesinduced atherosclerosis with particular emphasis on the molecular reactions that result in the modification of lipoproteins, and the consequences of these reactions on cellular metabolism. © 2006 Springer Science+Business Media, LLC. All rights reserved.
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