Antigenic and molecular characterization of avian influenza A(H9N2) viruses, Bangladesh

Shanmuganatham, K; Feeroz, MM; Jones-Engel, L; Smith, GJD; Fourment, M; Walker, D; McClenaghan, L; Alam, SMR; Hasan, MK; Seiler, P; Franks, J; Danner, A; Barman, S; McKenzie, P; Krauss, S; Webby, RJ; Webster, RG

Antigenic and molecular characterization of avian influenza A(H9N2) viruses, Bangladesh

Shanmuganatham, K Feeroz, MM Jones-Engel, L Smith, GJD Fourment, M

Walker, D McClenaghan, L Alam, SMR Hasan, MK Seiler, P Franks, J Danner, A Barman, S McKenzie, P Krauss, S Webby, RJ Webster, RG

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Publication Type:: Journal Article
Citation:: Emerging Infectious Diseases, 2013, 19 (9), pp. 1393 - 1402
Issue Date:: 2013-09-01

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Field	Value	Language
dc.contributor.author	Shanmuganatham, K	en_US
dc.contributor.author	Feeroz, MM	en_US
dc.contributor.author	Jones-Engel, L	en_US
dc.contributor.author	Smith, GJD	en_US
dc.contributor.author	Fourment, M https://orcid.org/0000-0001-8153-9822	en_US
dc.contributor.author	Walker, D	en_US
dc.contributor.author	McClenaghan, L	en_US
dc.contributor.author	Alam, SMR	en_US
dc.contributor.author	Hasan, MK	en_US
dc.contributor.author	Seiler, P	en_US
dc.contributor.author	Franks, J	en_US
dc.contributor.author	Danner, A	en_US
dc.contributor.author	Barman, S	en_US
dc.contributor.author	McKenzie, P	en_US
dc.contributor.author	Krauss, S	en_US
dc.contributor.author	Webby, RJ	en_US
dc.contributor.author	Webster, RG	en_US
dc.date.issued	2013-09-01	en_US
dc.identifier.citation	Emerging Infectious Diseases, 2013, 19 (9), pp. 1393 - 1402	en_US
dc.identifier.issn	1080-6040	en_US
dc.identifier.uri	http://hdl.handle.net/10453/116592
dc.description.abstract	Human infection with avian influenza A(H9N2) virus was identified in Bangladesh in 2011. Surveillance for influenza viruses in apparently healthy poultry in live-bird markets in Bangladesh during 2008-2011 showed that subtype H9N2 viruses are isolated year-round, whereas highly pathogenic subtype H5N1 viruses are co-isolated with subtype H9N2 primarily during the winter months. Phylogenetic analysis of the subtype H9N2 viruses showed that they are reassortants possessing 3 gene segments related to subtype H7N3; the remaining gene segments were from the subtype H9N2 G1 clade. We detected no reassortment with subtype H5N1 viruses. Serologic analyses of subtype H9N2 viruses from chickens revealed antigenic conservation, whereas analyses of viruses from quail showed antigenic drift. Molecular analysis showed that multiple mammalianspecific mutations have become fixed in the subtype H9N2 viruses, including changes in the hemagglutinin, matrix, and polymerase proteins. Our results indicate that these viruses could mutate to be transmissible from birds to mammals, including humans.	en_US
dc.relation.ispartof	Emerging Infectious Diseases	en_US
dc.relation.isbasedon	10.3201/eid1909.130336	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Chickens	en_US
dc.subject.mesh	Quail	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Antigens, Viral	en_US
dc.subject.mesh	Prevalence	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Genes, Viral	en_US
dc.subject.mesh	Molecular Sequence Data	en_US
dc.subject.mesh	Bangladesh	en_US
dc.subject.mesh	Influenza, Human	en_US
dc.subject.mesh	Influenza in Birds	en_US
dc.subject.mesh	Influenza A Virus, H9N2 Subtype	en_US
dc.title	Antigenic and molecular characterization of avian influenza A(H9N2) viruses, Bangladesh	en_US
dc.type	Journal Article
utslib.citation.volume	9	en_US
utslib.citation.volume	19	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1108 Medical Microbiology	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	9	en_US
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

Human infection with avian influenza A(H9N2) virus was identified in Bangladesh in 2011. Surveillance for influenza viruses in apparently healthy poultry in live-bird markets in Bangladesh during 2008-2011 showed that subtype H9N2 viruses are isolated year-round, whereas highly pathogenic subtype H5N1 viruses are co-isolated with subtype H9N2 primarily during the winter months. Phylogenetic analysis of the subtype H9N2 viruses showed that they are reassortants possessing 3 gene segments related to subtype H7N3; the remaining gene segments were from the subtype H9N2 G1 clade. We detected no reassortment with subtype H5N1 viruses. Serologic analyses of subtype H9N2 viruses from chickens revealed antigenic conservation, whereas analyses of viruses from quail showed antigenic drift. Molecular analysis showed that multiple mammalianspecific mutations have become fixed in the subtype H9N2 viruses, including changes in the hemagglutinin, matrix, and polymerase proteins. Our results indicate that these viruses could mutate to be transmissible from birds to mammals, including humans.

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http://hdl.handle.net/10453/116592