New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217

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Journal Article
Journal of Biological Chemistry, 2013, 288 (15), pp. 10616 - 10627
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Background: Classical zinc finger proteins are extremely abundant and interact with DNA using a well defined recognition code. Results: We solved the structure of ZNF217 bound to its cognate DNA. Conclusion: ZNF217 presents a unique DNA interaction pattern including a new type of protein-DNA contact. Significance: This study deepens our understanding of DNA recognition by classical zinc fingers. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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