New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217

Vandevenne, M; Jacques, DA; Artuz, C; Nguyen, CD; Kwan, AHY; Segal, DJ; Matthews, JM; Crossley, M; Guss, JM; MacKay, JP

New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217

Vandevenne, M Jacques, DA

Artuz, C Nguyen, CD Kwan, AHY Segal, DJ Matthews, JM Crossley, M Guss, JM MacKay, JP

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Publication Type:: Journal Article
Citation:: Journal of Biological Chemistry, 2013, 288 (15), pp. 10616 - 10627
Issue Date:: 2013-04-12

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Field	Value	Language
dc.contributor.author	Vandevenne, M	en_US
dc.contributor.author	Jacques, DA https://orcid.org/0000-0002-6426-4510	en_US
dc.contributor.author	Artuz, C	en_US
dc.contributor.author	Nguyen, CD	en_US
dc.contributor.author	Kwan, AHY	en_US
dc.contributor.author	Segal, DJ	en_US
dc.contributor.author	Matthews, JM	en_US
dc.contributor.author	Crossley, M	en_US
dc.contributor.author	Guss, JM	en_US
dc.contributor.author	MacKay, JP	en_US
dc.date.issued	2013-04-12	en_US
dc.identifier.citation	Journal of Biological Chemistry, 2013, 288 (15), pp. 10616 - 10627	en_US
dc.identifier.issn	0021-9258	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117210
dc.description.abstract	Background: Classical zinc finger proteins are extremely abundant and interact with DNA using a well defined recognition code. Results: We solved the structure of ZNF217 bound to its cognate DNA. Conclusion: ZNF217 presents a unique DNA interaction pattern including a new type of protein-DNA contact. Significance: This study deepens our understanding of DNA recognition by classical zinc fingers. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.	en_US
dc.relation.ispartof	Journal of Biological Chemistry	en_US
dc.relation.isbasedon	10.1074/jbc.M112.441451	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Trans-Activators	en_US
dc.subject.mesh	Neoplasm Proteins	en_US
dc.subject.mesh	DNA	en_US
dc.subject.mesh	Crystallography, X-Ray	en_US
dc.subject.mesh	Zinc Fingers	en_US
dc.subject.mesh	Structure-Activity Relationship	en_US
dc.subject.mesh	Models, Molecular	en_US
dc.title	New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217	en_US
dc.type	Journal Article
utslib.citation.volume	15	en_US
utslib.citation.volume	288	en_US
utslib.for	060101 Analytical Biochemistry	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access
pubs.issue	15	en_US
pubs.publication-status	Published	en_US
pubs.volume	288	en_US

Abstract:

Background: Classical zinc finger proteins are extremely abundant and interact with DNA using a well defined recognition code. Results: We solved the structure of ZNF217 bound to its cognate DNA. Conclusion: ZNF217 presents a unique DNA interaction pattern including a new type of protein-DNA contact. Significance: This study deepens our understanding of DNA recognition by classical zinc fingers. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/117210