Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system

Meng, ZX; Xu, XX; Zheng, W; Zhou, HM; Li, L; Zheng, YF; Lou, X

Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system

Meng, ZX Xu, XX

Zheng, W Zhou, HM Li, L Zheng, YF Lou, X

Permalink

Publication Type:: Journal Article
Citation:: Colloids and Surfaces B: Biointerfaces, 2011, 84 (1), pp. 97 - 102
Issue Date:: 2011-05-01

Closed Access

	Filename	Description	Size
	mor.pdf	Published Version	558.14 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Meng, ZX	en_US
dc.contributor.author	Xu, XX https://orcid.org/0000-0002-2598-3766	en_US
dc.contributor.author	Zheng, W	en_US
dc.contributor.author	Zhou, HM	en_US
dc.contributor.author	Li, L	en_US
dc.contributor.author	Zheng, YF	en_US
dc.contributor.author	Lou, X	en_US
dc.date.available	2010-12-14	en_US
dc.date.issued	2011-05-01	en_US
dc.identifier.citation	Colloids and Surfaces B: Biointerfaces, 2011, 84 (1), pp. 97 - 102	en_US
dc.identifier.issn	0927-7765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117929
dc.description.abstract	Drug (Fenbufen, FBF)-loaded poly(d,. l-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking time and pH value of the buffer solution on FBF release behavior of the resulting nanofibrous scaffolds were investigated, with the corresponding FBF-loaded PLGA and PLGA/gelatin solvent-cast films as controls. The release rate of FBF was found to be increased with the increment of gelatin content for all the composite samples, and the FBF release rate of aligned nanofibrous scaffold was lower than that of randomly oriented scaffold. Moreover, the crosslinking treatment depressed effectively the burst release of FBF at initial release stage of PLGA/gelatin (9/1) nanofibrous scaffold. In addition, the pH value of the buffer solution could change the physical state of the polymer and affect the FBF release rate. © 2010 Elsevier B.V.	en_US
dc.relation.ispartof	Colloids and Surfaces B: Biointerfaces	en_US
dc.relation.isbasedon	10.1016/j.colsurfb.2010.12.022	en_US
dc.subject.classification	Chemical Physics	en_US
dc.subject.mesh	Phenylbutyrates	en_US
dc.subject.mesh	Lactic Acid	en_US
dc.subject.mesh	Polyglycolic Acid	en_US
dc.subject.mesh	Gelatin	en_US
dc.subject.mesh	Microscopy, Electron, Scanning	en_US
dc.subject.mesh	Drug Delivery Systems	en_US
dc.subject.mesh	Nanofibers	en_US
dc.subject.mesh	Polylactic Acid-Polyglycolic Acid Copolymer	en_US
dc.title	Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	84	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0904 Chemical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	84	en_US

Abstract:

Drug (Fenbufen, FBF)-loaded poly(d,. l-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking time and pH value of the buffer solution on FBF release behavior of the resulting nanofibrous scaffolds were investigated, with the corresponding FBF-loaded PLGA and PLGA/gelatin solvent-cast films as controls. The release rate of FBF was found to be increased with the increment of gelatin content for all the composite samples, and the FBF release rate of aligned nanofibrous scaffold was lower than that of randomly oriented scaffold. Moreover, the crosslinking treatment depressed effectively the burst release of FBF at initial release stage of PLGA/gelatin (9/1) nanofibrous scaffold. In addition, the pH value of the buffer solution could change the physical state of the polymer and affect the FBF release rate. © 2010 Elsevier B.V.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/117929