Electrospun Chitosan-graft-PLGA nanofibres with significantly enhanced hydrophilicity and improved mechanical property

Li, AD; Sun, ZZ; Zhou, M; Xu, XX; Ma, JY; Zheng, W; Zhou, HM; Li, L; Zheng, YF

Electrospun Chitosan-graft-PLGA nanofibres with significantly enhanced hydrophilicity and improved mechanical property

Li, AD Sun, ZZ Zhou, M Xu, XX

Ma, JY Zheng, W Zhou, HM Li, L Zheng, YF

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Publication Type:: Journal Article
Citation:: Colloids and Surfaces B: Biointerfaces, 2013, 102 pp. 674 - 681
Issue Date:: 2013-02-01

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Field	Value	Language
dc.contributor.author	Li, AD	en_US
dc.contributor.author	Sun, ZZ	en_US
dc.contributor.author	Zhou, M	en_US
dc.contributor.author	Xu, XX https://orcid.org/0000-0002-2598-3766	en_US
dc.contributor.author	Ma, JY	en_US
dc.contributor.author	Zheng, W	en_US
dc.contributor.author	Zhou, HM	en_US
dc.contributor.author	Li, L	en_US
dc.contributor.author	Zheng, YF	en_US
dc.date.available	2012-09-20	en_US
dc.date.issued	2013-02-01	en_US
dc.identifier.citation	Colloids and Surfaces B: Biointerfaces, 2013, 102 pp. 674 - 681	en_US
dc.identifier.issn	0927-7765	en_US
dc.identifier.uri	http://hdl.handle.net/10453/118142
dc.description.abstract	This work reported a novel poly(lactic-co-glycolic acid) (PLGA) composite nanofibres, Chitosan-graft-PLGA (CS-graft-PLGA), produced by the electrospinning technique. CS was grafted onto the PLGA surface via the cross-linking agents reacting with the PLGA with reactive carboxyl groups on its surfaces introduced from the alkali treatment. The CS grafting ratios of the electrospun CS-graft-PLGA nanofibres were about 2.43%, 4.34%, 16.97% and 39.4% after cross-linked for 12. h, 16. h, 20. h and 24. h, respectively. The electrospun CS-graft-PLGA nanofibres were significantly uniform and highly smooth without the occurrence of bead defects, even at high CS grafting ratio. The electrospun CS-graft-PLGA nanofibres not only possessed the improved hydrophilicity and the protein absorption property, but also maintained the good mechanical property. In addition, the CS grafting can be conducive to accelerate degradation rate of PLGA. © 2012 Elsevier B.V.	en_US
dc.relation.ispartof	Colloids and Surfaces B: Biointerfaces	en_US
dc.relation.isbasedon	10.1016/j.colsurfb.2012.09.035	en_US
dc.subject.classification	Chemical Physics	en_US
dc.subject.mesh	Lactic Acid	en_US
dc.subject.mesh	Chitosan	en_US
dc.subject.mesh	Polyglycolic Acid	en_US
dc.subject.mesh	Nanofibers	en_US
dc.subject.mesh	Hydrophobic and Hydrophilic Interactions	en_US
dc.subject.mesh	Polylactic Acid-Polyglycolic Acid Copolymer	en_US
dc.title	Electrospun Chitosan-graft-PLGA nanofibres with significantly enhanced hydrophilicity and improved mechanical property	en_US
dc.type	Journal Article
utslib.citation.volume	102	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0904 Chemical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	102	en_US

Abstract:

This work reported a novel poly(lactic-co-glycolic acid) (PLGA) composite nanofibres, Chitosan-graft-PLGA (CS-graft-PLGA), produced by the electrospinning technique. CS was grafted onto the PLGA surface via the cross-linking agents reacting with the PLGA with reactive carboxyl groups on its surfaces introduced from the alkali treatment. The CS grafting ratios of the electrospun CS-graft-PLGA nanofibres were about 2.43%, 4.34%, 16.97% and 39.4% after cross-linked for 12. h, 16. h, 20. h and 24. h, respectively. The electrospun CS-graft-PLGA nanofibres were significantly uniform and highly smooth without the occurrence of bead defects, even at high CS grafting ratio. The electrospun CS-graft-PLGA nanofibres not only possessed the improved hydrophilicity and the protein absorption property, but also maintained the good mechanical property. In addition, the CS grafting can be conducive to accelerate degradation rate of PLGA. © 2012 Elsevier B.V.

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http://hdl.handle.net/10453/118142