Aluminum triflate catalyzed tandem reactions of d -galactal: Toward chiral benzopyrans, chromenes, and chromans

Publication Type:
Journal Article
Organic Letters, 2014, 16 (17), pp. 4543 - 4545
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© 2014 American Chemical Society. 3,4,6-Tri-O-acetyl-d-galactal is selectively converted into 1-O-aryl-2-deoxy derivatives or chiral bridged benzopyrans under Al(OTf)3 catalysis, depending on reaction conditions. The benzopyrans react with Al(OTf)3/acetic anhydride in ring-opening reactions in the absence or presence of acetic acid to selectively produce chiral chromenes or chromans, respectively, in high yields.
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