Relationship between the baseline alveolar volume-to-total lung capacity ratio and airway responsiveness

Kaminsky, DA; Daud, A; Chapman, DG

Relationship between the baseline alveolar volume-to-total lung capacity ratio and airway responsiveness

Kaminsky, DA Daud, A Chapman, DG

Permalink

Publication Type:: Journal Article
Citation:: Respirology, 2014, 19 (7), pp. 1046 - 1051
Issue Date:: 2014-01-01

Closed Access

	Filename	Description	Size
	Kaminsky_et_al-2014-Respirology.pdf	Published Version	197.82 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Kaminsky, DA	en_US
dc.contributor.author	Daud, A	en_US
dc.contributor.author	Chapman, DG https://orcid.org/0000-0002-8211-1817	en_US
dc.date.available	2014-05-22	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Respirology, 2014, 19 (7), pp. 1046 - 1051	en_US
dc.identifier.issn	1323-7799	en_US
dc.identifier.uri	http://hdl.handle.net/10453/118814
dc.description.abstract	© 2014 Asian Pacific Society of Respirology. Background and objective: Ventilation heterogeneity (VH) has been linked to airway responsiveness (AR) based on various measures of VH involving inert gas washout, forced oscillation and lung imaging. We explore whether VH at baseline, as measured by the simple ratio of single breath alveolar volume to plethysmographically determined total lung capacity (VA/TLC), would correlate with AR as measured by methacholine challenge testing. Methods: We analysed data from spirometry, lung volumes, diffusing capacity and methacholine challenge to derive the VA/TLCand the dose-response slope (DRS) of forced expiratory volume in 1 s (DRS-FEV1) during methacholine challenge from 136 patients. We separated out airway closure versus narrowing by examining the DRS for forced vital capacity (DRS-FVC) and the DRS for FEV1/FVC (DRS-FEV1/FVC), respectively. Similarly, we calculated the DRS for sGaw (DRSsGaw) as another measure of airway narrowing. We performed statistical analysis using Spearman rank correlation and multifactor linear regression using a backward stepwise modelling procedure. Results: We found that the DRS-FEV1 correlated with baseline VA/TLC (rho = -0.26, P < 0.01), and VA/TLC and FEV1 were independently associated with DRSFEV1 (R2 = 0.14, P = 0.01). In addition, VA/TLC was associated with both airway narrowing and closure in response to methacholine. Conclusions: These results confirm that baseline VA/TLC is associated with AR, and reflects both airway closure and airway narrowing following methacholine challenge.	en_US
dc.relation.ispartof	Respirology	en_US
dc.relation.isbasedon	10.1111/resp.12347	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Bronchial Hyperreactivity	en_US
dc.subject.mesh	Methacholine Chloride	en_US
dc.subject.mesh	Bronchoconstrictor Agents	en_US
dc.subject.mesh	Airway Resistance	en_US
dc.subject.mesh	Bronchial Provocation Tests	en_US
dc.subject.mesh	Total Lung Capacity	en_US
dc.subject.mesh	Pulmonary Diffusing Capacity	en_US
dc.subject.mesh	Forced Expiratory Volume	en_US
dc.subject.mesh	Spirometry	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Airway Remodeling	en_US
dc.title	Relationship between the baseline alveolar volume-to-total lung capacity ratio and airway responsiveness	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.citation.volume	19	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

© 2014 Asian Pacific Society of Respirology. Background and objective: Ventilation heterogeneity (VH) has been linked to airway responsiveness (AR) based on various measures of VH involving inert gas washout, forced oscillation and lung imaging. We explore whether VH at baseline, as measured by the simple ratio of single breath alveolar volume to plethysmographically determined total lung capacity (VA/TLC), would correlate with AR as measured by methacholine challenge testing. Methods: We analysed data from spirometry, lung volumes, diffusing capacity and methacholine challenge to derive the VA/TLCand the dose-response slope (DRS) of forced expiratory volume in 1 s (DRS-FEV1) during methacholine challenge from 136 patients. We separated out airway closure versus narrowing by examining the DRS for forced vital capacity (DRS-FVC) and the DRS for FEV1/FVC (DRS-FEV1/FVC), respectively. Similarly, we calculated the DRS for sGaw (DRSsGaw) as another measure of airway narrowing. We performed statistical analysis using Spearman rank correlation and multifactor linear regression using a backward stepwise modelling procedure. Results: We found that the DRS-FEV1 correlated with baseline VA/TLC (rho = -0.26, P < 0.01), and VA/TLC and FEV1 were independently associated with DRSFEV1 (R2 = 0.14, P = 0.01). In addition, VA/TLC was associated with both airway narrowing and closure in response to methacholine. Conclusions: These results confirm that baseline VA/TLC is associated with AR, and reflects both airway closure and airway narrowing following methacholine challenge.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/118814