Structure of the hemoglobin-isdh complex reveals the molecular basis of iron capture by staphylococcus aureus

Publication Type:
Journal Article
Citation:
Journal of Biological Chemistry, 2014, 289 (10), pp. 6728 - 6738
Issue Date:
2014-03-07
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Background: IsdB and IsdH proteins from Staphylococcus aureus strip heme iron from human hemoglobin. Results: The IsdH·hemoglobin complex shows how globin-binding and heme-binding NEAT domains of IsdH cooperate to remove heme from both chains of hemoglobin. Conclusion: The supradomain architecture of IsdH confers activity by precisely positioning the heme acceptor domain. Significance: Multiple IsdH·hemoglobin interfaces may be targets for new antibiotics. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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