The contrasting phylodynamics of human inuenza B viruses

Vijaykrishna, D; Holmes, EC; Joseph, U; Fourment, M; Su, YCF; Halpin, R; Lee, RTC; Deng, YM; Gunalan, V; Lin, X; Stockwell, TB; Fedorova, NB; Zhou, B; Spirason, N; Küuhnert, D; Bošková, V; Stadler, T; Costa, AM; Dwyer, DE; Huang, QS; Jennings, LC; Rawlinson, W; Sullivan, SG; Hurt, AC; Maurer-Stroh, S; Wentworth, DE; Smith, GJD; Barr, IG

The contrasting phylodynamics of human inuenza B viruses

Vijaykrishna, D Holmes, EC Joseph, U Fourment, M

Su, YCF Halpin, R Lee, RTC Deng, YM Gunalan, V Lin, X Stockwell, TB Fedorova, NB Zhou, B Spirason, N Küuhnert, D Bošková, V Stadler, T Costa, AM Dwyer, DE Huang, QS Jennings, LC Rawlinson, W Sullivan, SG Hurt, AC Maurer-Stroh, S Wentworth, DE Smith, GJD Barr, IG

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Publication Type:: Journal Article
Citation:: eLife, 2015, 2015 (4)
Issue Date:: 2015-01-16

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Field	Value	Language
dc.contributor.author	Vijaykrishna, D	en_US
dc.contributor.author	Holmes, EC	en_US
dc.contributor.author	Joseph, U	en_US
dc.contributor.author	Fourment, M https://orcid.org/0000-0001-8153-9822	en_US
dc.contributor.author	Su, YCF	en_US
dc.contributor.author	Halpin, R	en_US
dc.contributor.author	Lee, RTC	en_US
dc.contributor.author	Deng, YM	en_US
dc.contributor.author	Gunalan, V	en_US
dc.contributor.author	Lin, X	en_US
dc.contributor.author	Stockwell, TB	en_US
dc.contributor.author	Fedorova, NB	en_US
dc.contributor.author	Zhou, B	en_US
dc.contributor.author	Spirason, N	en_US
dc.contributor.author	Küuhnert, D	en_US
dc.contributor.author	Bošková, V	en_US
dc.contributor.author	Stadler, T	en_US
dc.contributor.author	Costa, AM	en_US
dc.contributor.author	Dwyer, DE	en_US
dc.contributor.author	Huang, QS	en_US
dc.contributor.author	Jennings, LC	en_US
dc.contributor.author	Rawlinson, W	en_US
dc.contributor.author	Sullivan, SG	en_US
dc.contributor.author	Hurt, AC	en_US
dc.contributor.author	Maurer-Stroh, S	en_US
dc.contributor.author	Wentworth, DE	en_US
dc.contributor.author	Smith, GJD	en_US
dc.contributor.author	Barr, IG	en_US
dc.date.available	2015-01-15	en_US
dc.date.issued	2015-01-16	en_US
dc.identifier.citation	eLife, 2015, 2015 (4)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/119149
dc.description.abstract	© 2015, eLife Sciences Publications Ltd. All rights reserved. A complex interplay of viral, host and ecological factors shape the spatio-temporal incidence and evolution of human inuenza viruses. Although considerable attention has been paid to inuenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for inuenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of inuenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection and receptor binding preference. In sum, this work identifies new factors that are important determinants of inuenza B evolution and epidemiology.	en_US
dc.relation.ispartof	eLife	en_US
dc.relation.isbasedon	10.7554/eLife.05055	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Dogs	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Reassortant Viruses	en_US
dc.subject.mesh	Influenza A virus	en_US
dc.subject.mesh	Influenza B virus	en_US
dc.subject.mesh	Asparagine	en_US
dc.subject.mesh	Hemagglutinin Glycoproteins, Influenza Virus	en_US
dc.subject.mesh	Antigens, Viral	en_US
dc.subject.mesh	Age Distribution	en_US
dc.subject.mesh	Evolution, Molecular	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Glycosylation	en_US
dc.subject.mesh	Genome, Viral	en_US
dc.subject.mesh	Models, Molecular	en_US
dc.subject.mesh	Time Factors	en_US
dc.subject.mesh	Victoria	en_US
dc.subject.mesh	New Zealand	en_US
dc.subject.mesh	Influenza, Human	en_US
dc.subject.mesh	Genetic Variation	en_US
dc.subject.mesh	Selection, Genetic	en_US
dc.subject.mesh	Madin Darby Canine Kidney Cells	en_US
dc.title	The contrasting phylodynamics of human inuenza B viruses	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	2015	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	2015	en_US

Abstract:

© 2015, eLife Sciences Publications Ltd. All rights reserved. A complex interplay of viral, host and ecological factors shape the spatio-temporal incidence and evolution of human inuenza viruses. Although considerable attention has been paid to inuenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for inuenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of inuenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection and receptor binding preference. In sum, this work identifies new factors that are important determinants of inuenza B evolution and epidemiology.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/119149