Enhanced expression of CD31/platelet endothelial cell adhesion molecule 1 (PECAM1) correlates with hypoxia inducible factor-1 alpha (HIF-1oc) in human glioblastoma multiforme

Musumeci, G; Castorina, A; Magro, G; Cardile, V; Castorina, S; Ribattie, D

Enhanced expression of CD31/platelet endothelial cell adhesion molecule 1 (PECAM1) correlates with hypoxia inducible factor-1 alpha (HIF-1oc) in human glioblastoma multiforme

Musumeci, G Castorina, A

Magro, G Cardile, V Castorina, S Ribattie, D

Permalink

Publication Type:: Journal Article
Citation:: Experimental Cell Research, 2015, 339 (2), pp. 407 - 416
Issue Date:: 2015-08-23

Closed Access

	Filename	Description	Size
	curt.pdf	Published Version	11.92 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Musumeci, G	en_US
dc.contributor.author	Castorina, A https://orcid.org/0000-0001-7037-759X	en_US
dc.contributor.author	Magro, G	en_US
dc.contributor.author	Cardile, V	en_US
dc.contributor.author	Castorina, S	en_US
dc.contributor.author	Ribattie, D	en_US
dc.date.available	2015-09-11	en_US
dc.date.issued	2015-08-23	en_US
dc.identifier.citation	Experimental Cell Research, 2015, 339 (2), pp. 407 - 416	en_US
dc.identifier.issn	0014-4827	en_US
dc.identifier.uri	http://hdl.handle.net/10453/119190
dc.description.abstract	© 2015 Elsevier Inc. Glioblastoma multiforme (GBM) is characterized by numerous abnormal blood vessels, which rapidly proliferate and invade brain tissue and express different angiogenic factors. In this study we have investigated whether t h e expression levels of CD31/PECAM1 are deregulated in human GBM tissue specimens and we have also correlated t h e expression levels of CD31/PECAM1 w i th those of HIF-1α. Finally, we have established a correlation between t h e expression levels of CD31/PECAM1 a n d HIF-1α, and those of two other biomarkers, namely N-cadherin and ADAM-10, of aggressiveness in t h e same tumors. Results have shown an increased expression of CD31/PECAM1 correlated to HIF-1α expression, confirming evidence demonstrating that different types of tumor are able to trigger aberrant angiogenesis through HIF-1α. Moreover, we also established a further correlation among CD31/PECAM1 and HIF-1α and N-cadherin and ADAM-10, t w o other markers of aggressiveness in t h e same tumors.	en_US
dc.relation.ispartof	Experimental Cell Research	en_US
dc.relation.isbasedon	10.1016/j.yexcr.2015.09.007	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Glioblastoma	en_US
dc.subject.mesh	Brain Neoplasms	en_US
dc.subject.mesh	Neovascularization, Pathologic	en_US
dc.subject.mesh	Antigens, CD31	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Hypoxia-Inducible Factor 1, alpha Subunit	en_US
dc.subject.mesh	Platelet Endothelial Cell Adhesion Molecule-1	en_US
dc.title	Enhanced expression of CD31/platelet endothelial cell adhesion molecule 1 (PECAM1) correlates with hypoxia inducible factor-1 alpha (HIF-1oc) in human glioblastoma multiforme	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	339	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	339	en_US

Abstract:

© 2015 Elsevier Inc. Glioblastoma multiforme (GBM) is characterized by numerous abnormal blood vessels, which rapidly proliferate and invade brain tissue and express different angiogenic factors. In this study we have investigated whether t h e expression levels of CD31/PECAM1 are deregulated in human GBM tissue specimens and we have also correlated t h e expression levels of CD31/PECAM1 w i th those of HIF-1α. Finally, we have established a correlation between t h e expression levels of CD31/PECAM1 a n d HIF-1α, and those of two other biomarkers, namely N-cadherin and ADAM-10, of aggressiveness in t h e same tumors. Results have shown an increased expression of CD31/PECAM1 correlated to HIF-1α expression, confirming evidence demonstrating that different types of tumor are able to trigger aberrant angiogenesis through HIF-1α. Moreover, we also established a further correlation among CD31/PECAM1 and HIF-1α and N-cadherin and ADAM-10, t w o other markers of aggressiveness in t h e same tumors.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/119190