Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer

Naz, M; Nasiri, N; Ikram, M; Nafees, M; Qureshi, MZ; Ali, S; Tricoli, A

Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer

Naz, M Nasiri, N

Ikram, M

Nafees, M

Qureshi, MZ Ali, S Tricoli, A

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Publication Type:: Journal Article
Citation:: Applied Nanoscience (Switzerland), 2017, 7 (8), pp. 793 - 802
Issue Date:: 2017-01-01

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Field	Value	Language
dc.contributor.author	Naz, M	en_US
dc.contributor.author	Nasiri, N https://orcid.org/0000-0003-4738-098X	en_US
dc.contributor.author	Ikram, M https://orcid.org/0000-0001-7741-789X	en_US
dc.contributor.author	Nafees, M https://orcid.org/0000-0002-8739-1459	en_US
dc.contributor.author	Qureshi, MZ	en_US
dc.contributor.author	Ali, S	en_US
dc.contributor.author	Tricoli, A	en_US
dc.date.issued	2017-01-01	en_US
dc.identifier.citation	Applied Nanoscience (Switzerland), 2017, 7 (8), pp. 793 - 802	en_US
dc.identifier.issn	2190-5509	en_US
dc.identifier.uri	http://hdl.handle.net/10453/120204
dc.description.abstract	© The Author(s) 2017. The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet–visible (UV–Vis) spectrophotometry. Anticancer activity of Ag-NPs (5–20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.	en_US
dc.relation.ispartof	Applied Nanoscience (Switzerland)	en_US
dc.relation.isbasedon	10.1007/s13204-017-0615-6	en_US
dc.title	Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	7	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

© The Author(s) 2017. The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet–visible (UV–Vis) spectrophotometry. Anticancer activity of Ag-NPs (5–20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.

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http://hdl.handle.net/10453/120204