Mechanochemical synthesis of zinc-apatitic calcium phosphate and the controlled zinc release for bone tissue engineering

Hattori, Y; Mori, H; Chou, J; Otsuka, M

Mechanochemical synthesis of zinc-apatitic calcium phosphate and the controlled zinc release for bone tissue engineering

Hattori, Y Mori, H Chou, J

Otsuka, M

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Publication Type:: Journal Article
Citation:: Drug Development and Industrial Pharmacy, 2016, 42 (4), pp. 595 - 601
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Hattori, Y	en_US
dc.contributor.author	Mori, H	en_US
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Otsuka, M	en_US
dc.date.issued	2016-01-01	en_US
dc.identifier.citation	Drug Development and Industrial Pharmacy, 2016, 42 (4), pp. 595 - 601	en_US
dc.identifier.issn	0363-9045	en_US
dc.identifier.uri	http://hdl.handle.net/10453/120306
dc.description.abstract	© 2015 Taylor & Francis. In this study, in order to control zinc (Zn)-release from calcium phosphate (CaP), the crystalline forms of CaP-containing Zn were modified by wet ball milling and/or heat treatment. The CaP (CaO:CaHPO4:ZnO=7:20:3, molar ratio) was ground in a ball mill with the addition of purified water, and the ground products were heated to 400 °C and 800 °C. The physicochemical properties of these ground products were measured by powder X-ray diffraction (XRD), infrared spectroscopy (IR), scanning electron microscopy and energy-dispersive X-ray spectroscopy. Zn release characteristics from the samples were evaluated using a dissolution tester. The results of XRD and IR suggested that the structures of the starting materials were destroyed after 2.5 h of grinding, and new apatite-like amorphous solid containing Zn was generated. The Zn-release from the ground products was markedly suppressed after 2.5 h of grinding.	en_US
dc.relation.ispartof	Drug Development and Industrial Pharmacy	en_US
dc.relation.isbasedon	10.3109/03639045.2015.1061537	en_US
dc.subject.mesh	Calcium Phosphates	en_US
dc.subject.mesh	Apatites	en_US
dc.subject.mesh	Zinc	en_US
dc.subject.mesh	Delayed-Action Preparations	en_US
dc.subject.mesh	X-Ray Diffraction	en_US
dc.subject.mesh	Tissue Engineering	en_US
dc.subject.mesh	Bone Regeneration	en_US
dc.subject.mesh	Chemistry, Pharmaceutical	en_US
dc.title	Mechanochemical synthesis of zinc-apatitic calcium phosphate and the controlled zinc release for bone tissue engineering	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	42	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	42	en_US

Abstract:

© 2015 Taylor & Francis. In this study, in order to control zinc (Zn)-release from calcium phosphate (CaP), the crystalline forms of CaP-containing Zn were modified by wet ball milling and/or heat treatment. The CaP (CaO:CaHPO4:ZnO=7:20:3, molar ratio) was ground in a ball mill with the addition of purified water, and the ground products were heated to 400 °C and 800 °C. The physicochemical properties of these ground products were measured by powder X-ray diffraction (XRD), infrared spectroscopy (IR), scanning electron microscopy and energy-dispersive X-ray spectroscopy. Zn release characteristics from the samples were evaluated using a dissolution tester. The results of XRD and IR suggested that the structures of the starting materials were destroyed after 2.5 h of grinding, and new apatite-like amorphous solid containing Zn was generated. The Zn-release from the ground products was markedly suppressed after 2.5 h of grinding.

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http://hdl.handle.net/10453/120306