PHARMENZYMONETICS AND PHARMGEONETICS: A NEW DOOR IN PHARMACOLOGY
- WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
- Publication Type:
- Journal Article
- WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2016, 5 (2), pp. 1424 - 1432 (8)
- Issue Date:
To introduce a new vision with an enhanced focus on the major factors contributing to pharmacokinetics and pharmacodynamics outputs at the level of both new drug introduction and clinical use of already appreciated medicines. Effect of enzymes, environment and genetic makeup on the pharmacology is discussed with a review of past focus by the scientists on such factors. The two terms are used for the first time solving the utmost problem in achieving therapeutic results by the scientists and patients. The meaning of two terms used in previous researches is illustrated briefly. People living in different countries experience different kinetic concentrations of medicines than literature value due to environment changes, enzyme variability and genetic transformations. Cmax, half-life, Vd, renal clearance and urinary excretion studies depicted marked variation due to change of enzyme and environmental factors among the individual of various origins and even among various individuals of same origin. For that two terms are coined pharmenzymonetics and pharmgeonetics. Advanced effects of medicine are entertained, enlightening cutting edge focus on the enzyme, environment and genetics prior study and treatment with a medicine to gain ideal or near to ideal therapeutic output.
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