Multifunctional microsphere formulation of fluorescent magnetic properties for drug delivery system
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- Conference Proceeding
- AIP Conference Proceedings, 2017, 1817
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|AIP CONFERENCE Fluorescent Magnetic Microsphere for Drug Delivery 2017.pdf||Accepted Manuscript version||275.43 kB|
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© 2017 Author(s). The microsphere formulations of Chit/TPP/Sm/Fe3O4/Rn were prepared by an ionic gelation technique, where Chit=chitosan, TPP=tripolyphosphate, Sm=samarium and Rn=ranitidine. Optimum of microsphere formulation exhibit magnetic and fluorescent properties with adsorption efficiency of ∼92% was obtained for Chit/TPP/Sm/Fe3O4/Rn with ratio 400:500:50:1:20. Fluorescence intensity of microsphere formulations increased with the cumulative amount release of ranitidine, so that the changing of fluorescence intensity at wavelength of 590 nm referring to the Sm3+ion could be used as indicator in DDS. With the demonstration of sustained release from microsphere formulation, it allows to investigate the applications to other drugs.
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