TOTAL BODY CLEARANCE AND MEAN RESIDENCE TIME OF TAMOXIFEN IN FEMALE HEALTHY SUBJECTS

Shahbaz, K

TOTAL BODY CLEARANCE AND MEAN RESIDENCE TIME OF TAMOXIFEN IN FEMALE HEALTHY SUBJECTS

Shahbaz, K

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Publisher:: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL)
Publication Type:: Journal Article
Citation:: International Journal of Research and Development in Pharmacy and Life Sciences, 2016, 5 (3)
Issue Date:: 2016-03-01

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Field	Value	Language
dc.contributor.author	Shahbaz, K https://orcid.org/0000-0002-0030-9716	en_US
dc.date.issued	2016-03-01	en_US
dc.identifier.citation	International Journal of Research and Development in Pharmacy and Life Sciences, 2016, 5 (3)	en_US
dc.identifier.issn	2278-0238	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122033
dc.description.abstract	Objective: To investigate total body clearance and mean residence time after a single oral dose of tamoxifen in female healthy subjects focusing on two concepts pharmenzymonetics and pharmgeonetics for the first time in Pakistan. Methodology: Two parameters were investigated in eight healthy female subjects after single oral dose of 20mg tablet Nolvadex brand. Blood samples were collected and plasma concentration was determined by Gradient HPLC method to evaluate the total body clearance and mean resident time. Subjects were kept under observation for 4 weeks detecting any adverse signs or symptoms. Results: Value of total body clearance mean ±SE was 39.7 ± 0.55 L/Hr/Kg and that of mean residence time MRT is 15.18 ± 0.19 Hours. There were no adverse signs reported during 4 weeks of direct observation of subjects after oral single dose. Blood pressure, temperature, pulse rate and apparent activity of subjects remained normal. Conclusion: The total body clearance and MRT of tamoxifen is greater as compared to literature value in the healthy females of Pakistan due to pharmgeonetics.	en_US
dc.publisher	International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL)	en_US
dc.relation.ispartof	International Journal of Research and Development in Pharmacy and Life Sciences	en_US
dc.relation.isbasedon	10.21276/IJRDPL	en_US
dc.title	TOTAL BODY CLEARANCE AND MEAN RESIDENCE TIME OF TAMOXIFEN IN FEMALE HEALTHY SUBJECTS	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	5	en_US
utslib.location.activity	Australia	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	open_access
pubs.consider-herdc	true	en_US
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

Objective: To investigate total body clearance and mean residence time after a single oral dose of tamoxifen in female healthy subjects focusing on two concepts pharmenzymonetics and pharmgeonetics for the first time in Pakistan. Methodology: Two parameters were investigated in eight healthy female subjects after single oral dose of 20mg tablet Nolvadex brand. Blood samples were collected and plasma concentration was determined by Gradient HPLC method to evaluate the total body clearance and mean resident time. Subjects were kept under observation for 4 weeks detecting any adverse signs or symptoms. Results: Value of total body clearance mean ±SE was 39.7 ± 0.55 L/Hr/Kg and that of mean residence time MRT is 15.18 ± 0.19 Hours. There were no adverse signs reported during 4 weeks of direct observation of subjects after oral single dose. Blood pressure, temperature, pulse rate and apparent activity of subjects remained normal. Conclusion: The total body clearance and MRT of tamoxifen is greater as compared to literature value in the healthy females of Pakistan due to pharmgeonetics.

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http://hdl.handle.net/10453/122033