Elucidation of markers for monitoring morphine and its analogs in urine adulterated with pyridinium chlorochromate

Luong, S; Kuzhiumparambil, U; Fu, S

Elucidation of markers for monitoring morphine and its analogs in urine adulterated with pyridinium chlorochromate

Luong, S

Kuzhiumparambil, U

Fu, S

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Publication Type:: Journal Article
Citation:: Bioanalysis, 2015, 7 (18), pp. 2283 - 2295
Issue Date:: 2015-01-01

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Field	Value	Language
dc.contributor.author	Luong, S https://orcid.org/0000-0001-5000-0074	en_US
dc.contributor.author	Kuzhiumparambil, U https://orcid.org/0000-0003-0582-6779	en_US
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612	en_US
dc.date.issued	2015-01-01	en_US
dc.identifier.citation	Bioanalysis, 2015, 7 (18), pp. 2283 - 2295	en_US
dc.identifier.issn	1757-6180	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122277
dc.description.abstract	© 2015 Future Science Ltd. Aim: Currently, procedures that identify the drugs 'destroyed' in adulterated urine specimens are very limited. This study aimed to determine the effect of pyridinium chlorochromate (PCC) on routine opiate assays and identify reaction products formed. Results/methodology: Opiate-positive urines adulterated with PCC (20 and 100 mM) were analyzed using CEDIA® immunoassay and GC-MS. Urine and water samples spiked with 6-monoacetylmorphine, morphine and its glucuronides (10 μg/ml) and PCC (0.02-100 mM) were monitored with LC-MS, and the products characterized. Conclusion: PCC significantly decreased the abundance of morphine, codeine and IS. Adulterated water and urine samples containing 6-monoacetylmorphine, morphine and morphine-3-glucuronide yielded morphinone-3-glucuronide, 7,14-dihydroxy-6-monoacetylmorphine, 7,8-diketo-6-monoacetylmorphine and 7,8-diketo-morphine (tentative assignment). Reaction pathways may be different in the two matrices.	en_US
dc.relation.ispartof	Bioanalysis	en_US
dc.relation.isbasedon	10.4155/bio.15.131	en_US
dc.title	Elucidation of markers for monitoring morphine and its analogs in urine adulterated with pyridinium chlorochromate	en_US
dc.type	Journal Article
utslib.citation.volume	18	en_US
utslib.citation.volume	7	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	0301 Analytical Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - C3 - Climate Change Cluster
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.issue	18	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

© 2015 Future Science Ltd. Aim: Currently, procedures that identify the drugs 'destroyed' in adulterated urine specimens are very limited. This study aimed to determine the effect of pyridinium chlorochromate (PCC) on routine opiate assays and identify reaction products formed. Results/methodology: Opiate-positive urines adulterated with PCC (20 and 100 mM) were analyzed using CEDIA® immunoassay and GC-MS. Urine and water samples spiked with 6-monoacetylmorphine, morphine and its glucuronides (10 μg/ml) and PCC (0.02-100 mM) were monitored with LC-MS, and the products characterized. Conclusion: PCC significantly decreased the abundance of morphine, codeine and IS. Adulterated water and urine samples containing 6-monoacetylmorphine, morphine and morphine-3-glucuronide yielded morphinone-3-glucuronide, 7,14-dihydroxy-6-monoacetylmorphine, 7,8-diketo-6-monoacetylmorphine and 7,8-diketo-morphine (tentative assignment). Reaction pathways may be different in the two matrices.

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http://hdl.handle.net/10453/122277