A study to model the post-mortem stability of 4-MMC, MDMA and BZP in putrefying remains

Wenholz, DS; Luong, S; Philp, M; Forbes, SL; Stuart, BH; Drummer, OH; Fu, S

A study to model the post-mortem stability of 4-MMC, MDMA and BZP in putrefying remains

Wenholz, DS

Luong, S

Philp, M

Forbes, SL

Stuart, BH

Drummer, OH Fu, S

Permalink

Publication Type:: Journal Article
Citation:: Forensic Science International, 2016, 265 pp. 54 - 60
Issue Date:: 2016-08-01

Closed Access

	Filename	Description	Size
	A Study to.pdf	Published Version	1.16 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Wenholz, DS https://orcid.org/0000-0002-5526-4359	en_US
dc.contributor.author	Luong, S https://orcid.org/0000-0001-5000-0074	en_US
dc.contributor.author	Philp, M https://orcid.org/0000-0001-6308-1635	en_US
dc.contributor.author	Forbes, SL https://orcid.org/0000-0001-7416-0080	en_US
dc.contributor.author	Stuart, BH https://orcid.org/0000-0001-9540-4435	en_US
dc.contributor.author	Drummer, OH	en_US
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612	en_US
dc.date.available	2016-01-08	en_US
dc.date.issued	2016-08-01	en_US
dc.identifier.citation	Forensic Science International, 2016, 265 pp. 54 - 60	en_US
dc.identifier.issn	0379-0738	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122650
dc.description.abstract	© 2016 Elsevier Ireland Ltd. There is currently limited data available on the stabilities of the three stimulants 4-methylmethcathinone (4-MMC), 3,4-methylenedioxymethamphetamine (MDMA) and N-benzylpiperazine (BZP) in a putrefying matrix. A Gas Chromatography Mass Spectrometry (GC-MS) method to determine the concentration of the three drugs in putrefying porcine liver over a three month period was developed and validated. Both 4-MMC and BZP were found to be unstable, becoming undetectable and having an average recovery of 52% respectively after one month at ambient room temperature (20. °C). MDMA was found to be moderately stable, with an average recovery of 74% after three months at room temperature. This study indicated that the putrefaction process could have a significant impact on concentrations of 4-MMC and BZP in post-mortem cases involving putrefied remains.	en_US
dc.relation.ispartof	Forensic Science International	en_US
dc.relation.isbasedon	10.1016/j.forsciint.2016.01.006	en_US
dc.subject.classification	Legal & Forensic Medicine	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Swine	en_US
dc.subject.mesh	Postmortem Changes	en_US
dc.subject.mesh	Methamphetamine	en_US
dc.subject.mesh	N-Methyl-3,4-methylenedioxyamphetamine	en_US
dc.subject.mesh	Piperazines	en_US
dc.subject.mesh	Street Drugs	en_US
dc.subject.mesh	Reproducibility of Results	en_US
dc.subject.mesh	Models, Animal	en_US
dc.subject.mesh	Substance Abuse Detection	en_US
dc.subject.mesh	Forensic Pathology	en_US
dc.subject.mesh	Illicit Drugs	en_US
dc.title	A study to model the post-mortem stability of 4-MMC, MDMA and BZP in putrefying remains	en_US
dc.type	Journal Article
utslib.citation.volume	265	en_US
utslib.for	039902 Forensic Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	265	en_US

Abstract:

© 2016 Elsevier Ireland Ltd. There is currently limited data available on the stabilities of the three stimulants 4-methylmethcathinone (4-MMC), 3,4-methylenedioxymethamphetamine (MDMA) and N-benzylpiperazine (BZP) in a putrefying matrix. A Gas Chromatography Mass Spectrometry (GC-MS) method to determine the concentration of the three drugs in putrefying porcine liver over a three month period was developed and validated. Both 4-MMC and BZP were found to be unstable, becoming undetectable and having an average recovery of 52% respectively after one month at ambient room temperature (20. °C). MDMA was found to be moderately stable, with an average recovery of 74% after three months at room temperature. This study indicated that the putrefaction process could have a significant impact on concentrations of 4-MMC and BZP in post-mortem cases involving putrefied remains.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/122650