Iron and dopamine: A toxic couple

Hare, DJ; Double, KL

Iron and dopamine: A toxic couple

Hare, DJ

Double, KL

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Publication Type:: Journal Article
Citation:: Brain, 2016, 139 (4), pp. 1026 - 1035
Issue Date:: 2016-04-01

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Field	Value	Language
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Double, KL	en_US
dc.date.issued	2016-04-01	en_US
dc.identifier.citation	Brain, 2016, 139 (4), pp. 1026 - 1035	en_US
dc.identifier.issn	0006-8950	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122677
dc.description.abstract	© 2016 The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream mechanisms that precipitate cell death in this disorder. Although an elevation in brain iron levels is a normal feature of ageing, the increase is greater in Parkinson's disease; on the other hand, the effects of the disease are most marked in the nigrostriatal dopaminergic system. In this Update, we explain that neurodegeneration in the affected regions may result from the potent redox couple formed by iron and dopamine itself, and discuss the clinical implications of this molecular trait in this dynamic and rapidly moving area of Parkinson's disease research.	en_US
dc.relation.ispartof	Brain	en_US
dc.relation.isbasedon	10.1093/brain/aww022	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Substantia Nigra	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Parkinson Disease	en_US
dc.subject.mesh	Iron	en_US
dc.subject.mesh	Reactive Oxygen Species	en_US
dc.subject.mesh	Dopamine	en_US
dc.title	Iron and dopamine: A toxic couple	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	139	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	139	en_US

Abstract:

© 2016 The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream mechanisms that precipitate cell death in this disorder. Although an elevation in brain iron levels is a normal feature of ageing, the increase is greater in Parkinson's disease; on the other hand, the effects of the disease are most marked in the nigrostriatal dopaminergic system. In this Update, we explain that neurodegeneration in the affected regions may result from the potent redox couple formed by iron and dopamine itself, and discuss the clinical implications of this molecular trait in this dynamic and rapidly moving area of Parkinson's disease research.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/122677