808 nm photocontrolled UCL imaging guided chemo/photothermal synergistic therapy with single UCNPs-CuS@PAA nanocomposite

Liu, B; Li, C; Xie, Z; Hou, Z; Cheng, Z; Jin, D; Lin, J

808 nm photocontrolled UCL imaging guided chemo/photothermal synergistic therapy with single UCNPs-CuS@PAA nanocomposite

Liu, B Li, C Xie, Z Hou, Z Cheng, Z Jin, D

Lin, J

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Publication Type:: Journal Article
Citation:: Dalton Transactions, 2016, 45 (33), pp. 13061 - 13069
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Liu, B	en_US
dc.contributor.author	Li, C	en_US
dc.contributor.author	Xie, Z	en_US
dc.contributor.author	Hou, Z	en_US
dc.contributor.author	Cheng, Z	en_US
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666	en_US
dc.contributor.author	Lin, J	en_US
dc.date.issued	2016-01-01	en_US
dc.identifier.citation	Dalton Transactions, 2016, 45 (33), pp. 13061 - 13069	en_US
dc.identifier.issn	1477-9226	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122815
dc.description.abstract	© The Royal Society of Chemistry 2016. Recently, incorporating multiple components into one nanostructured matrix to construct a multifunctional nanomedical platform has attracted more and more attention for simultaneous anticancer diagnosis and therapy. Herein, a novel anti-cancer nanoplatform has been successfully developed by coating a uniform shell of poly(acrylic acid) (PAA) on the surface of CuS-decorated upconversion nanoparticles (UCNPs). Benefiting from the enhanced 808 nm-excited UCL intensity of the multilayer UCNPs, the unique photothermal properties of CuS and the pH-responsive drug release capacity of the PAA shell, such a nanoplatform design of UCNPs-CuS@PAA (labeled UCP) offers a new route to achieve 808 nm-excited UCL imaging guided chemo/photothermal combination therapy. We have found that the combined chemo/photothermal therapy can significantly improve the therapeutic efficacy compared with chemotherapy or photothermal therapy (PTT) alone. Moreover, the pH/NIR-dependent drug delivery properties, 808 nm-excited UCL imaging, as well as in vitro/in vivo biocompatibility tests were also investigated in detail. These results show promising applications of UCP nanoparticles as a novel theranostic agent for the detection and treatment of tumors.	en_US
dc.relation.ispartof	Dalton Transactions	en_US
dc.relation.isbasedon	10.1039/c5dt04857e	en_US
dc.subject.classification	Inorganic & Nuclear Chemistry	en_US
dc.subject.mesh	Cell Line, Tumor	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Neoplasms	en_US
dc.subject.mesh	Copper	en_US
dc.subject.mesh	Doxorubicin	en_US
dc.subject.mesh	Acrylic Resins	en_US
dc.subject.mesh	Antineoplastic Agents	en_US
dc.subject.mesh	Microscopy, Fluorescence	en_US
dc.subject.mesh	Phototherapy	en_US
dc.subject.mesh	Tumor Burden	en_US
dc.subject.mesh	Light	en_US
dc.subject.mesh	Nanoparticles	en_US
dc.title	808 nm photocontrolled UCL imaging guided chemo/photothermal synergistic therapy with single UCNPs-CuS@PAA nanocomposite	en_US
dc.type	Journal Article
utslib.citation.volume	33	en_US
utslib.citation.volume	45	en_US
utslib.for	0302 Inorganic Chemistry	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0307 Theoretical and Computational Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.issue	33	en_US
pubs.publication-status	Published	en_US
pubs.volume	45	en_US

Abstract:

© The Royal Society of Chemistry 2016. Recently, incorporating multiple components into one nanostructured matrix to construct a multifunctional nanomedical platform has attracted more and more attention for simultaneous anticancer diagnosis and therapy. Herein, a novel anti-cancer nanoplatform has been successfully developed by coating a uniform shell of poly(acrylic acid) (PAA) on the surface of CuS-decorated upconversion nanoparticles (UCNPs). Benefiting from the enhanced 808 nm-excited UCL intensity of the multilayer UCNPs, the unique photothermal properties of CuS and the pH-responsive drug release capacity of the PAA shell, such a nanoplatform design of UCNPs-CuS@PAA (labeled UCP) offers a new route to achieve 808 nm-excited UCL imaging guided chemo/photothermal combination therapy. We have found that the combined chemo/photothermal therapy can significantly improve the therapeutic efficacy compared with chemotherapy or photothermal therapy (PTT) alone. Moreover, the pH/NIR-dependent drug delivery properties, 808 nm-excited UCL imaging, as well as in vitro/in vivo biocompatibility tests were also investigated in detail. These results show promising applications of UCP nanoparticles as a novel theranostic agent for the detection and treatment of tumors.

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http://hdl.handle.net/10453/122815