Nano-assembly of nanodiamonds by conjugation to actin filaments

Publication Type:
Journal Article
Journal of Biophotonics, 2016, 9 (3), pp. 296 - 304
Issue Date:
Filename Description Size
Bradac_et_al-2016-Journal_of_Biophotonics.pdfPublished Version237.92 kB
Adobe PDF
Full metadata record
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Fluorescent nanodiamonds (NDs) are remarkable objects. They possess unique mechanical and optical properties combined with high surface areas and controllable surface reactivity. They are non-toxic and hence suited for use in biological environments. NDs are also readily available and commercially inexpensive. Here, the exceptional capability of controlling and tailoring their surface chemistry is demonstrated. Small, bright diamond nanocrystals (size 30 nm) are conjugated to protein filaments of actin (length 3-7 μm). The conjugation to actin filaments is extremely selective and highly target-specific. These unique features, together with the relative simplicity of the conjugation-targeting method, make functionalised nanodiamonds a powerful and versatile platform in biomedicine and quantum nanotechnologies. Applications ranging from using NDs as superior biological markers to, potentially, developing novel bottom-up approaches for the fabrication of hybrid quantum devices that would bridge across the bio/solid-state interface are presented and discussed.
Please use this identifier to cite or link to this item: