Translational aspects of the human respiratory virome

Mitchell, AB; Oliver, BGG; Glanville, AR

Translational aspects of the human respiratory virome

Mitchell, AB Oliver, BGG

Glanville, AR

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Publication Type:: Journal Article
Citation:: American Journal of Respiratory and Critical Care Medicine, 2016, 194 (12), pp. 1458 - 1464
Issue Date:: 2016-12-15

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Field	Value	Language
dc.contributor.author	Mitchell, AB	en_US
dc.contributor.author	Oliver, BGG https://orcid.org/0000-0002-7122-9262	en_US
dc.contributor.author	Glanville, AR	en_US
dc.date.issued	2016-12-15	en_US
dc.identifier.citation	American Journal of Respiratory and Critical Care Medicine, 2016, 194 (12), pp. 1458 - 1464	en_US
dc.identifier.issn	1073-449X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122890
dc.description.abstract	© 2016 by the American Thoracic Society. Despite the dominant role of community-acquired respiratory viruses as etiological agents of disease, there has been little focus to date on the translation of rapidly developing diagnostic modalities, such as next-generation sequencing techniques in the examination of lower respiratory tract samples. When applied, these techniques should inform strategies to both understand the nexus between health and disease states of the respiratory virome, and drive a paradigm shift in how the practicing pulmonologist views the conceptual framework of respiratory infections. The lower respiratory tract was once thought to be a sanctuary site from microbiological colonization owing to the efficacy of upper airway-protective mechanisms and the host mucosal barrier function of the lower airways, combined with both innate and adaptive immune responses.As a small number of recent studies confirm, this is a naive vision of the lung, the viral component of which parallels recent revelations from respiratory microbiome studies. Hence, it is now timely to revise our thinking regarding the constituents, diversity, and changing nature of the respiratory virome in health and disease. One area worthy of focus is the interface between community-acquired respiratory viruses and the respiratory virome to better understand the dynamics in acute infection, as well as the factors that may lead to viral persistence and chronic disease. Given recent advances in metagenomics, the tools are now at hand to accomplish these goals.	en_US
dc.relation.ispartof	American Journal of Respiratory and Critical Care Medicine	en_US
dc.relation.isbasedon	10.1164/rccm.201606-1278CI	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Respiratory System	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Respiratory Tract Infections	en_US
dc.subject.mesh	Translational Medical Research	en_US
dc.subject.mesh	Microbiota	en_US
dc.title	Translational aspects of the human respiratory virome	en_US
dc.type	Journal Article
utslib.citation.volume	12	en_US
utslib.citation.volume	194	en_US
utslib.for	1116 Medical Physiology	en_US
utslib.for	110203 Respiratory Diseases	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	12	en_US
pubs.publication-status	Published	en_US
pubs.volume	194	en_US

Abstract:

© 2016 by the American Thoracic Society. Despite the dominant role of community-acquired respiratory viruses as etiological agents of disease, there has been little focus to date on the translation of rapidly developing diagnostic modalities, such as next-generation sequencing techniques in the examination of lower respiratory tract samples. When applied, these techniques should inform strategies to both understand the nexus between health and disease states of the respiratory virome, and drive a paradigm shift in how the practicing pulmonologist views the conceptual framework of respiratory infections. The lower respiratory tract was once thought to be a sanctuary site from microbiological colonization owing to the efficacy of upper airway-protective mechanisms and the host mucosal barrier function of the lower airways, combined with both innate and adaptive immune responses.As a small number of recent studies confirm, this is a naive vision of the lung, the viral component of which parallels recent revelations from respiratory microbiome studies. Hence, it is now timely to revise our thinking regarding the constituents, diversity, and changing nature of the respiratory virome in health and disease. One area worthy of focus is the interface between community-acquired respiratory viruses and the respiratory virome to better understand the dynamics in acute infection, as well as the factors that may lead to viral persistence and chronic disease. Given recent advances in metagenomics, the tools are now at hand to accomplish these goals.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/122890