Nanosilver and the microbiological activity of the particulate solids versus the leached soluble silver

Faiz, MB; Amal, R; Marquis, CP; Harry, EJ; Sotiriou, GA; Rice, SA; Gunawan, C

Nanosilver and the microbiological activity of the particulate solids versus the leached soluble silver

Faiz, MB Amal, R Marquis, CP Harry, EJ

Sotiriou, GA Rice, SA

Gunawan, C

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Publication Type:: Journal Article
Citation:: Nanotoxicology, 2018, 12 (3), pp. 263 - 273
Issue Date:: 2018-03-16

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Field	Value	Language
dc.contributor.author	Faiz, MB	en_US
dc.contributor.author	Amal, R	en_US
dc.contributor.author	Marquis, CP	en_US
dc.contributor.author	Harry, EJ https://orcid.org/0000-0003-0858-9473	en_US
dc.contributor.author	Sotiriou, GA	en_US
dc.contributor.author	Rice, SA https://orcid.org/0000-0002-9486-2343	en_US
dc.contributor.author	Gunawan, C https://orcid.org/0000-0002-2957-1347	en_US
dc.date.issued	2018-03-16	en_US
dc.identifier.citation	Nanotoxicology, 2018, 12 (3), pp. 263 - 273	en_US
dc.identifier.issn	1743-5390	en_US
dc.identifier.uri	http://hdl.handle.net/10453/124059
dc.description.abstract	© 2018 Informa UK Limited, trading as Taylor & Francis Group. Nanosilver (Ag NPs) is currently one of the most commercialized antimicrobial nanoparticles with as yet, still unresolved cytotoxicity origins. To date, research efforts have mostly described the antimicrobial contribution from the leaching of soluble silver, while the undissolved solid Ag particulates are often considered as being microbiologically inert, serving only as source of the cytotoxic Ag ions. Here, we show the rapid stimulation of lethal cellular oxidative stress in bacteria by the presence of the undissolved Ag particulates. The cytotoxicity characteristics are distinct from those arising from the leached soluble Ag, the latter being locked in organic complexes. The work also highlights the unique oxidative stress-independent bacterial toxicity of silver salt. Taken together, the findings advocate that future enquiries on the antimicrobial potency and also importantly, the environmental and clinical impact of Ag NPs use, should pay attention to the potential bacterial toxicological responses to the undissolved Ag particulates, rather than just to the leaching of soluble silver. The findings also put into question the common use of silver salt as model material for evaluating bacterial toxicity of Ag NPs.	en_US
dc.relation.ispartof	Nanotoxicology	en_US
dc.relation.isbasedon	10.1080/17435390.2018.1434910	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Bacillus subtilis	en_US
dc.subject.mesh	Silver	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Cell Proliferation	en_US
dc.subject.mesh	Oxidative Stress	en_US
dc.subject.mesh	Solubility	en_US
dc.subject.mesh	Microbial Viability	en_US
dc.subject.mesh	Metal Nanoparticles	en_US
dc.title	Nanosilver and the microbiological activity of the particulate solids versus the leached soluble silver	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	12	en_US
utslib.for	1007 Nanotechnology	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	12	en_US

Abstract:

© 2018 Informa UK Limited, trading as Taylor & Francis Group. Nanosilver (Ag NPs) is currently one of the most commercialized antimicrobial nanoparticles with as yet, still unresolved cytotoxicity origins. To date, research efforts have mostly described the antimicrobial contribution from the leaching of soluble silver, while the undissolved solid Ag particulates are often considered as being microbiologically inert, serving only as source of the cytotoxic Ag ions. Here, we show the rapid stimulation of lethal cellular oxidative stress in bacteria by the presence of the undissolved Ag particulates. The cytotoxicity characteristics are distinct from those arising from the leached soluble Ag, the latter being locked in organic complexes. The work also highlights the unique oxidative stress-independent bacterial toxicity of silver salt. Taken together, the findings advocate that future enquiries on the antimicrobial potency and also importantly, the environmental and clinical impact of Ag NPs use, should pay attention to the potential bacterial toxicological responses to the undissolved Ag particulates, rather than just to the leaching of soluble silver. The findings also put into question the common use of silver salt as model material for evaluating bacterial toxicity of Ag NPs.

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http://hdl.handle.net/10453/124059