Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review

Pasin, D; Cawley, A; Bidny, S; Fu, S

Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review

Pasin, D

Cawley, A Bidny, S Fu, S

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Publication Type:: Journal Article
Citation:: Analytical and Bioanalytical Chemistry, 2017, 409 (25), pp. 5821 - 5836
Issue Date:: 2017-10-01

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Field	Value	Language
dc.contributor.author	Pasin, D https://orcid.org/0000-0002-5037-7290	en_US
dc.contributor.author	Cawley, A	en_US
dc.contributor.author	Bidny, S	en_US
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612	en_US
dc.date.available	2017-05-30	en_US
dc.date.issued	2017-10-01	en_US
dc.identifier.citation	Analytical and Bioanalytical Chemistry, 2017, 409 (25), pp. 5821 - 5836	en_US
dc.identifier.issn	1618-2642	en_US
dc.identifier.uri	http://hdl.handle.net/10453/124102
dc.description.abstract	© 2017, Springer-Verlag Berlin Heidelberg. The proliferation of new psychoactive substances (NPS) in recent years has resulted in the development of numerous analytical methods for the detection and identification of known and unknown NPS derivatives. High-resolution mass spectrometry (HRMS) has been identified as the method of choice for broad screening of NPS in a wide range of analytical contexts because of its ability to measure accurate masses using data-independent acquisition (DIA) techniques. Additionally, it has shown promise for non-targeted screening strategies that have been developed in order to detect and identify novel analogues without the need for certified reference materials (CRMs) or comprehensive mass spectral libraries. This paper reviews the applications of HRMS for the analysis of NPS in forensic drug chemistry and analytical toxicology. It provides an overview of the sample preparation procedures in addition to data acquisition, instrumental analysis, and data processing techniques. Furthermore, it gives an overview of the current state of non-targeted screening strategies with discussion on future directions and perspectives of this technique. [Figure not available: see fulltext.].	en_US
dc.relation.ispartof	Analytical and Bioanalytical Chemistry	en_US
dc.relation.isbasedon	10.1007/s00216-017-0441-4	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Psychotropic Drugs	en_US
dc.subject.mesh	Designer Drugs	en_US
dc.subject.mesh	Specimen Handling	en_US
dc.subject.mesh	Chemical Fractionation	en_US
dc.subject.mesh	Substance Abuse Detection	en_US
dc.subject.mesh	Forensic Medicine	en_US
dc.subject.mesh	Mass Spectrometry	en_US
dc.title	Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review	en_US
dc.type	Journal Article
utslib.citation.volume	25	en_US
utslib.citation.volume	409	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access
pubs.issue	25	en_US
pubs.publication-status	Published	en_US
pubs.volume	409	en_US

Abstract:

© 2017, Springer-Verlag Berlin Heidelberg. The proliferation of new psychoactive substances (NPS) in recent years has resulted in the development of numerous analytical methods for the detection and identification of known and unknown NPS derivatives. High-resolution mass spectrometry (HRMS) has been identified as the method of choice for broad screening of NPS in a wide range of analytical contexts because of its ability to measure accurate masses using data-independent acquisition (DIA) techniques. Additionally, it has shown promise for non-targeted screening strategies that have been developed in order to detect and identify novel analogues without the need for certified reference materials (CRMs) or comprehensive mass spectral libraries. This paper reviews the applications of HRMS for the analysis of NPS in forensic drug chemistry and analytical toxicology. It provides an overview of the sample preparation procedures in addition to data acquisition, instrumental analysis, and data processing techniques. Furthermore, it gives an overview of the current state of non-targeted screening strategies with discussion on future directions and perspectives of this technique. [Figure not available: see fulltext.].

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http://hdl.handle.net/10453/124102