Ultrasensitive electrochemical detection of H<inf>2</inf>O<inf>2</inf> in living cells based on ultrathin MnO<inf>2</inf> nanosheets
- Publication Type:
- Journal Article
- Sensors and Actuators, B: Chemical, 2017, 252 pp. 72 - 78
- Issue Date:
© 2017 Elsevier B.V. Using a facile and efficient method, two-dimensional (2D) ultra-thin MnO2 nanosheets were successfully prepared. Due to the large specific surface area and mesoporous structure, MnO2 nanosheet is a good candidate for use as an enhanced electrochemical sensing material. MnO2 nanosheets were immobilized onto glassy carbon electrodes with Nafion film to construct a H2O2 electrochemical nonenzymatic sensor. Amperometric study showed MnO2 nanosheets exhibited very high electrocatalytic activity towards H2O2 reduction. A very low detection limit (5 nM) was reached with a wide linear range (25 nM–2 μM and 10–454 μM) and a high sensitivity of 3261 mA M−1 cm−2. The fabricated H2O2 sensor also exhibited excellent selectivity, good reproducibility and long-time stability. Furthermore, the constructed high sensitive sensor was successfully applied to perform real-time monitoring trace concentration of H2O2 released by SP2/0 cells, indicating that MnO2 nanosheets provide a new platform for developing high performance electrochemical sensors in biological applications.
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