Recent Progress in Near Infrared Light Triggered Photodynamic Therapy

Deng, K; Li, C; Huang, S; Xing, B; Jin, D; Zeng, Q; Hou, Z; Lin, J

Recent Progress in Near Infrared Light Triggered Photodynamic Therapy

Deng, K Li, C Huang, S Xing, B Jin, D

Zeng, Q Hou, Z Lin, J

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Publication Type:: Journal Article
Citation:: Small, 2017, 13 (44)
Issue Date:: 2017-11-27

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Field	Value	Language
dc.contributor.author	Deng, K	en_US
dc.contributor.author	Li, C	en_US
dc.contributor.author	Huang, S	en_US
dc.contributor.author	Xing, B	en_US
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666	en_US
dc.contributor.author	Zeng, Q	en_US
dc.contributor.author	Hou, Z	en_US
dc.contributor.author	Lin, J	en_US
dc.date.issued	2017-11-27	en_US
dc.identifier.citation	Small, 2017, 13 (44)	en_US
dc.identifier.issn	1613-6810	en_US
dc.identifier.uri	http://hdl.handle.net/10453/124767
dc.description.abstract	© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Nowadays, photodynamic therapy (PDT) is under the research spotlight as an appealing modality for various malignant tumors. Compared with conventional PDT treatment activated by ultraviolet or visible light, near infrared (NIR) light-triggered PDT possessing deeper penetration to lesion area and lower photodamage to normal tissue holds great potential for in vivo deep-seated tumor. In this review, recent research progress related to the exploration of NIR light responsive PDT nanosystems is summarized. To address current obstacles of PDT treatment and facilitate the effective utilization, several innovative strategies are developed and introduced into PDT nanosystems, including the conjugation with targeted moieties, O2 self-sufficient PDT, dual photosensitizers (PSs)-loaded PDT nanoplatform, and PDT-involved synergistic therapy. Finally, the potential challenges as well as the prospective for further development are also discussed.	en_US
dc.relation.ispartof	Small	en_US
dc.relation.isbasedon	10.1002/smll.201702299	en_US
dc.subject.classification	Nanoscience & Nanotechnology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Antineoplastic Agents	en_US
dc.subject.mesh	Photosensitizing Agents	en_US
dc.subject.mesh	Photochemotherapy	en_US
dc.subject.mesh	Infrared Rays	en_US
dc.subject.mesh	Nanoparticles	en_US
dc.title	Recent Progress in Near Infrared Light Triggered Photodynamic Therapy	en_US
dc.type	Journal Article
utslib.citation.volume	44	en_US
utslib.citation.volume	13	en_US
utslib.for	1007 Nanotechnology	en_US
utslib.for	MD Multidisciplinary	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.issue	44	en_US
pubs.publication-status	Published	en_US
pubs.volume	13	en_US

Abstract:

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Nowadays, photodynamic therapy (PDT) is under the research spotlight as an appealing modality for various malignant tumors. Compared with conventional PDT treatment activated by ultraviolet or visible light, near infrared (NIR) light-triggered PDT possessing deeper penetration to lesion area and lower photodamage to normal tissue holds great potential for in vivo deep-seated tumor. In this review, recent research progress related to the exploration of NIR light responsive PDT nanosystems is summarized. To address current obstacles of PDT treatment and facilitate the effective utilization, several innovative strategies are developed and introduced into PDT nanosystems, including the conjugation with targeted moieties, O2 self-sufficient PDT, dual photosensitizers (PSs)-loaded PDT nanoplatform, and PDT-involved synergistic therapy. Finally, the potential challenges as well as the prospective for further development are also discussed.

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http://hdl.handle.net/10453/124767